{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:36:13Z","timestamp":1790422573549,"version":"4.1.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,9,27]],"date-time":"2013-09-27T00:00:00Z","timestamp":1380240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>Intratesticular injection of EsterilSol (zinc gluconate neutralized with arginine) is a chemical sterilant for male dogs sometimes used in population control campaigns. Adverse reactions have been reported in 1% to 4% of treated dogs, but detailed histomorphologic descriptions are lacking. During a behavioral study conducted in the Chilean Patagonia in 2012, severe necrosuppurative orchitis and ulcerative dermatitis were observed in 2 of 36 (6%) dogs sterilized with EsterilSol according to the manufacturer\u2019s instructions. Reactions were noted on days 8 and 7 postinjection and required scrotal ablation on days 8 and 13, respectively; neither reaction was associated with the injection site. Although self-trauma following administration may have contributed, the cause of the adverse reactions is uncertain. EsterilSol is a relatively uncomplicated method to sterilize male dogs, but the occurrence of severe adverse reactions several days after administration emphasizes the need for the provision of long-term monitoring and veterinary care during sterilization campaigns using this product.<\/jats:p>","DOI":"10.1177\/0300985813505875","type":"journal-article","created":{"date-parts":[[2013,9,28]],"date-time":"2013-09-28T00:26:45Z","timestamp":1380328005000},"page":"820-823","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Necrosuppurative Orchitis and Scrotal Necrotizing Dermatitis Following Intratesticular Administration of Zinc Gluconate Neutralized With Arginine (EsterilSol) in 2 Mixed-Breed Dogs"],"prefix":"10.1177","volume":"51","author":[{"given":"M. J.","family":"Forz\u00e1n","sequence":"first","affiliation":[{"name":"Canadian Cooperative Wildlife Health Centre, Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Garde","sequence":"additional","affiliation":[{"name":"Veterinarians without Borders\/Veterinarios sin Fronteras-Canada, Latin America Regional Office, Valdivia, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. E.","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Veterinarians without Borders\/Veterinarios sin Fronteras-Canada, Latin America Regional Office, Valdivia, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. V.","family":"Vanderstichel","sequence":"additional","affiliation":[{"name":"Department of Health Management, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,9,27]]},"reference":[{"key":"bibr1-0300985813505875","unstructured":"Esquivel LaCroix C. Evaluation of a single intratesticular injection of zinc gluconate neutralized by arginine (Neutersol\u00ae) as a chemical sterilant in sexually mature male dogs. In: Proceedings of the Third International Symposium on Non-Surgical Contraceptive Methods for Pet Population Control. 2006;20. www.acc-d.org\/2006%20Symposium%20Docs\/5Esquivel_R.pdf. Accessed March 31 2013."},{"key":"bibr2-0300985813505875","unstructured":"EsterilSol Veterinary Training Manual 2010. Baltimore MD: Ark Sciences, LLC. http:\/\/www.arksciences.com\/Files\/Training_Manual_English.pdf. Accessed May 10 2013."},{"key":"bibr3-0300985813505875","first-page":"55","volume-title":"The State of the Animals IV","author":"Jackman J","year":"2007"},{"key":"bibr4-0300985813505875","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.69.1.140"},{"key":"bibr5-0300985813505875","doi-asserted-by":"publisher","DOI":"10.1079\/9780851994369.0000"},{"key":"bibr6-0300985813505875","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2007.03.026"},{"key":"bibr7-0300985813505875","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0531.2008.01119.x"},{"issue":"5","key":"bibr8-0300985813505875","first-page":"686","volume":"88","author":"Tepsumethanon V","year":"2005","journal-title":"J Med Assoc Thai"},{"key":"bibr9-0300985813505875","unstructured":"US Food and Drug Administration. Freedom of Information Summary: Neutersol\u00ae injectable solution for dogs (zinc gluconate neutralized by arginine). New Animal Drug Application (NADA) 141\u2013217. 2003. http:\/\/www.fda.gov\/downloads\/AnimalVeterinary\/Products\/ApprovedAnimalDrugProducts\/FOIADrugSummari-es\/ucm118024.pdf. Accessed March 31 2013."},{"key":"bibr10-0300985813505875","volume-title":"Risk Analysis: A Quantitative Guide","author":"Vose D","year":"2008"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985813505875","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300985813505875","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985813505875","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:53:59Z","timestamp":1777661639000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300985813505875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,27]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1177\/0300985813505875"],"URL":"https:\/\/doi.org\/10.1177\/0300985813505875","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,27]]}}}