{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:16:26Z","timestamp":1793229386859,"version":"4.5.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,5,30]],"date-time":"2014-05-30T00:00:00Z","timestamp":1401408000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>\n                    Cytochrome P450 1B1 ( CYP1B1) is highly expressed in human and murine ocular tissues during development. Mutations in this gene are implicated in the development of primary congenital glaucoma (PCG) in humans. Mice deficient in Cyp1b1 ( Cyp1b1\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    ) present developmental abnormalities similar to human primary congenital glaucoma. The present work describes the ultrastructural morphology of the iridocorneal angle of 21 eyes from 1-week-old to 8-month-old Cyp1b1\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice. Morphometric and semiquantitative analysis of the data revealed that 3-week-old Cyp1b1\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice present a significantly ( P &lt; .005) decreased amount of trabecular meshwork (TM) collagen and higher TM endothelial cell and collagen lesion scores ( P &lt; .005) than age-matched controls. Collagen loss and lesion scores were progressively increased in older animals, with 8-month-old animals presenting severe atrophy of the TM. Our findings advance the understanding of the effects of CYP1B1 mutations in TM development and primary congenital glaucoma, as well as suggest a link between TM morphologic alterations and increased intraocular pressure.\n                  <\/jats:p>","DOI":"10.1177\/0300985814535613","type":"journal-article","created":{"date-parts":[[2014,5,30]],"date-time":"2014-05-30T22:09:28Z","timestamp":1401487768000},"page":"397-403","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":45,"title":["Ultrastructural Abnormalities of the Trabecular Meshwork Extracellular Matrix in\n                    <i>Cyp1b1<\/i>\n                    -Deficient Mice"],"prefix":"10.1177","volume":"52","author":[{"given":"L. B. C.","family":"Teixeira","sequence":"first","affiliation":[{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine, Madison, WI, USA"},{"name":"McPherson Eye Research Institute, University of Wisconsin, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. R.","family":"Dubielzig","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine, Madison, WI, USA"},{"name":"McPherson Eye Research Institute, University of Wisconsin, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. M.","family":"Sorenson","sequence":"additional","affiliation":[{"name":"McPherson Eye Research Institute, University of Wisconsin, Madison, WI, USA"},{"name":"Department of Pediatrics, University of Wisconsin, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Sheibani","sequence":"additional","affiliation":[{"name":"McPherson Eye Research Institute, University of Wisconsin, Madison, WI, USA"},{"name":"Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,5,30]]},"reference":[{"key":"bibr1-0300985814535613","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1955.00930010807003"},{"key":"bibr2-0300985814535613","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.11.027"},{"key":"bibr3-0300985814535613","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.106.014282"},{"key":"bibr4-0300985814535613","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2004.10.003"},{"key":"bibr5-0300985814535613","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19960301)33:4<336::AID-JEMT4>3.0.CO;2-N"},{"key":"bibr6-0300985814535613","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/18.2.391"},{"key":"bibr7-0300985814535613","first-page":"213","volume-title":"The Glaucomas","author":"Hernandez MR","year":"1996"},{"key":"bibr8-0300985814535613","doi-asserted-by":"publisher","DOI":"10.1126\/science.1080095"},{"key":"bibr9-0300985814535613","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(98)00011-1"},{"key":"bibr10-0300985814535613","volume-title":"The Development of the Human Eye","author":"Mann IC","year":"1928"},{"key":"bibr11-0300985814535613","first-page":"507","volume":"56","author":"Maumene AE","year":"1958","journal-title":"Trans Am Ophthalmol Soc"},{"key":"bibr12-0300985814535613","first-page":"1358","volume":"43","author":"Panicker SG","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr13-0300985814535613","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)36551-1"},{"key":"bibr14-0300985814535613","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-1-3"},{"key":"bibr15-0300985814535613","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200302000-00005"},{"key":"bibr16-0300985814535613","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.4.641"},{"key":"bibr17-0300985814535613","first-page":"629","volume":"10","author":"Stoilov I","year":"2004","journal-title":"Mol Vis"},{"key":"bibr18-0300985814535613","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)36803-5"},{"key":"bibr19-0300985814535613","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2009.02.007"},{"key":"bibr20-0300985814535613","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-415759-0.00053-4"},{"key":"bibr21-0300985814535613","doi-asserted-by":"publisher","DOI":"10.1086\/338709"},{"key":"bibr22-0300985814535613","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16257-0"},{"key":"bibr23-0300985814535613","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00856-13"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985814535613","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300985814535613","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985814535613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:54:56Z","timestamp":1777661696000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300985814535613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,30]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1177\/0300985814535613"],"URL":"https:\/\/doi.org\/10.1177\/0300985814535613","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,30]]}}}