{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:16:50Z","timestamp":1784830610235,"version":"3.55.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T00:00:00Z","timestamp":1422576000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>In Switzerland, dicrocoeliasis is regarded as the most significant parasitic infection of llamas and alpacas. Fasciola hepatica infestation is also a problem but less common. The aim of the present retrospective study was to evaluate the lungs of New World camelids (NWCs) for evidence of arterial hypertension in association with liver changes due to liver fluke infestation. The lungs of 20 llamas and 20 alpacas with liver fluke infestation were histologically evaluated. The hematoxylin and eosin and van Gieson (VG)\u2013elastica stains as well as immunohistology for the expression of \u03b1\u2013smooth muscle actin (\u03b1-SMA) were used to visualize the structures of arterial walls. Parasitology of fecal matter (11 llamas and 17 alpacas) confirmed that most of these animals were infested with both Dicrocoelium dendriticum and other gastrointestinal parasites. In most cases (10\/12 llamas, 4\/6 alpacas), liver enzyme activity in serum was elevated. Histologically, arteries in the lungs of 9 of 20 llamas (45%) and 3 of 20 alpacas (15%) showed severe intimal and adventitial and slight to moderate medial thickening, which was confirmed with \u03b1-SMA and VG-elastica staining. All animals exhibited typical liver changes, such as fibrosis and biliary hyperplasia, in association with the presence of liver flukes. This study shows that liver flukes can induce proliferative changes in lung arteries in NWCs that resemble those seen with pulmonary arterial hypertension due to liver parasites in humans. However, the degree of liver fluke infestation was not correlated with the extent of liver damage, or with the amount of thoracic or abdominal effusion or pulmonary arterial changes.<\/jats:p>","DOI":"10.1177\/0300985814564978","type":"journal-article","created":{"date-parts":[[2015,1,31]],"date-time":"2015-01-31T01:03:03Z","timestamp":1422666183000},"page":"1202-1209","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Pulmonary Arterial Lesions in New World Camelids in Association With\n                    <i>Dicrocoelium dendriticum<\/i>\n                    and\n                    <i>Fasciola hepatica<\/i>\n                    Infection"],"prefix":"10.1177","volume":"52","author":[{"given":"M.","family":"Hilbe","sequence":"first","affiliation":[{"name":"Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Robert","sequence":"additional","affiliation":[{"name":"Institute of Animal Pathology, Vetsuisse Faculty, University of Berne, Berne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pospischil","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gerspach","sequence":"additional","affiliation":[{"name":"Department of Farm Animals, Clinic of Ruminants, Vetsuisse Faculty, University of Zurich, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,1,30]]},"reference":[{"key":"bibr1-0300985814564978","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvfa.2009.02.003"},{"key":"bibr2-0300985814564978","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2003.09.008"},{"key":"bibr3-0300985814564978","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0720(15)31011-2"},{"key":"bibr4-0300985814564978","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201101-0146OC"},{"issue":"2","key":"bibr5-0300985814564978","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1590\/S1806-37132011000200018","volume":"37","author":"Correa R de A","year":"2011","journal-title":"J Bras Pneumol"},{"key":"bibr6-0300985814564978","volume-title":"Lehrbuch der Parasitologie f\u00fcr die Tiermedizin","author":"Deplazes P","year":"2013","edition":"3"},{"key":"bibr7-0300985814564978","doi-asserted-by":"publisher","DOI":"10.1136\/vr.145.11.315"},{"key":"bibr8-0300985814564978","first-page":"187","volume":"27","author":"Gunsser I","year":"1999","journal-title":"Tier\u00e4rztl Prax"},{"key":"bibr9-0300985814564978","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0048"},{"key":"bibr10-0300985814564978","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-5-592"},{"key":"bibr11-0300985814564978","doi-asserted-by":"publisher","DOI":"10.1136\/vr.162.13.424-a"},{"issue":"5","key":"bibr12-0300985814564978","first-page":"515","volume":"23","author":"H\u00e4nichen T","year":"1995","journal-title":"Tier\u00e4rztl Prax Ausg G"},{"key":"bibr13-0300985814564978","doi-asserted-by":"publisher","DOI":"10.1024\/0036-7281.147.8.335"},{"issue":"7","key":"bibr14-0300985814564978","first-page":"291","volume":"119","author":"Hertzberg H","year":"2006","journal-title":"Berl M\u00fcnch Tier\u00e4rztl Wochenschr"},{"key":"bibr15-0300985814564978","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070112"},{"key":"bibr16-0300985814564978","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16107-2"},{"issue":"8","key":"bibr17-0300985814564978","first-page":"1030","volume":"52","author":"Huffmyer JL","year":"2007","journal-title":"Respir Care"},{"key":"bibr18-0300985814564978","doi-asserted-by":"publisher","DOI":"10.1007\/BF02632344"},{"key":"bibr19-0300985814564978","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181d05aa7"},{"key":"bibr20-0300985814564978","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03308.x"},{"key":"bibr21-0300985814564978","doi-asserted-by":"publisher","DOI":"10.2460\/javma.228.5.756"},{"key":"bibr22-0300985814564978","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00217.2009"},{"key":"bibr23-0300985814564978","doi-asserted-by":"publisher","DOI":"10.1136\/vr.150.20.637"},{"key":"bibr24-0300985814564978","unstructured":"Kahn CM, Scott L. 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