{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:25:31Z","timestamp":1777919131825,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T00:00:00Z","timestamp":1426723200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>The Perdido Key beach mouse ( Peromyscus polionotus trissyllepsis) is a critically endangered subspecies of the oldfield mouse. The captive population, currently maintained by 3 Florida zoos, is entirely derived from just 3 wild-caught ancestor mice. Necropsy and histopathology revealed chordoma of the vertebral column in 38 of 88 (43%) mice. The tumors were locally expansile and invasive masses of large physaliferous (vacuolated) cells with small, round, hyperchromatic nuclei, similar to the \u201cclassic\u201d form of chordomas described in humans. Primary tumors rarely contained small amounts of bone and cartilaginous matrix, characteristic of the \u201cchondroid\u201d form. Neoplastic cells contained abundant granules positive by the periodic acid\u2013Schiff reaction. Brachyury and cytokeratin AE1\/AE3 were detected in neoplastic cells by immunohistochemistry, but uncoupling protein 1 was not identified. Primary tumors occurred along the entire vertebral column\u2014cervical, 5 of 38 (13%); thoracic, 16 (42%); lumbar, 13 (34%); and sacral, 10 (26%)\u2014and 10 (26%) mice had multiple primary masses. Metastases to the lungs were noted in 13 of the 38 (34%) mice. Mice diagnosed with chordomas postmortem ranged from 424 to 2170 days old, with a mean of 1399 days. The prevalence of chordoma was not significantly different between males ( n = 23 of 50; 46%) and females ( n = 15 of 38; 39%).<\/jats:p>","DOI":"10.1177\/0300985815575051","type":"journal-article","created":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T10:26:43Z","timestamp":1426847203000},"page":"163-169","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Chordomas at High Prevalence in the Captive Population of the Endangered Perdido Key Beach Mouse (\n                    <i>Peromyscus polionotus trissyllepsis<\/i>\n                    )"],"prefix":"10.1177","volume":"53","author":[{"given":"K. R.","family":"Taylor","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M.","family":"Garner","sequence":"additional","affiliation":[{"name":"Northwest ZooPath, Monroe, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Russell","sequence":"additional","affiliation":[{"name":"Santa Fe College Teaching Zoo, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. D.","family":"Epperson","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. A.","family":"Grodi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. R.","family":"Roff","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. A.","family":"Dumonceaux","sequence":"additional","affiliation":[{"name":"Palm Beach Zoo and Conservation Society, West Palm Beach, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"Struthers","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Dark","sequence":"additional","affiliation":[{"name":"Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Abbott","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,3,19]]},"reference":[{"key":"bibr1-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1293\/tox.22.205"},{"key":"bibr2-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000501)88:9<2122::AID-CNCR19>3.0.CO;2-1"},{"key":"bibr3-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1177\/0192623309335061"},{"key":"bibr4-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.013128"},{"key":"bibr5-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1177\/104063870802000529"},{"key":"bibr6-0300985815575051","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1990.197.02.240"},{"key":"bibr7-0300985815575051","doi-asserted-by":"publisher","DOI":"10.5625\/lar.2011.27.1.53"},{"key":"bibr8-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21805"},{"key":"bibr9-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1177\/030098588001700514"},{"key":"bibr10-0300985815575051","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.119312"},{"key":"bibr11-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1177\/0300985814537531"},{"key":"bibr12-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1177\/030098589102800602"},{"key":"bibr13-0300985815575051","volume-title":"FY 2011\u20132012 Progress Report on activities of the Florida Fish and Wildlife Conservation Commission, Endangered and Threatened Species Management and Conservation Plan","author":"Florida Fish and Wildlife Conservation Commission","year":"2012"},{"key":"bibr14-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1177\/030098588402100516"},{"key":"bibr15-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197308)32:2<410::AID-CNCR2820320219>3.0.CO;2-S"},{"key":"bibr16-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1177\/030098589002700411"},{"key":"bibr17-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196711)20:11<1841::AID-CNCR2820201107>3.0.CO;2-2"},{"key":"bibr18-0300985815575051","first-page":"253","volume":"75","author":"Irwin J","year":"2012","journal-title":"Peromyscus polionotus trissyllepsis. Fla Sci"},{"key":"bibr19-0300985815575051","doi-asserted-by":"publisher","DOI":"10.5858\/2009-0476-OA.1"},{"key":"bibr20-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23100"},{"key":"bibr21-0300985815575051","unstructured":"Linzey AV, NatureServe. Peromyscus polionotus. http:\/\/www.iucnredlist.org. Published 2008. Accessed January 26, 2014."},{"key":"bibr22-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008947301735"},{"key":"bibr23-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20000701)87:1<68::AID-IJC10>3.0.CO;2-V"},{"key":"bibr24-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1177\/104063870401600516"},{"key":"bibr25-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1177\/104063870301500312"},{"key":"bibr26-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2419"},{"key":"bibr27-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1638\/1042-7260(2000)031[0107:TVCIAD]2.0.CO;2"},{"key":"bibr28-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11421"},{"key":"bibr29-0300985815575051","volume-title":"Perdido Key Beach Mouse Studbook: Peromyscus polionotus trissylepsis","author":"Russell K","year":"2013"},{"key":"bibr30-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.1184"},{"key":"bibr31-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1177\/030098588802500106"},{"key":"bibr32-0300985815575051","first-page":"347","volume":"37","author":"Stefanski SA","year":"1987","journal-title":"Lab Anim Sci"},{"key":"bibr33-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980123)75:3<335::AID-AJMG23>3.0.CO;2-P"},{"key":"bibr34-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1186\/1751-0147-53-55"},{"key":"bibr35-0300985815575051","unstructured":"US Fish and Wildlife Service, Region IV.\n                      Recovery Plan for the Alabama Beach Mouse\n                      (Peromyscus polionotus ammobates)\n                      , Perdido Key Beach Mouse\n                      (P p trissyllepsis)\n                      , and Choctawhatchee Beach Mouse\n                      (P p allophrys). Atlanta, GA: US Fish and Wildlife Service, Region IV; 1987."},{"key":"bibr36-0300985815575051","unstructured":"US Fish and Wildlife Service, Southeast Region.\n                      Perdido Key Beach Mouse\n                      (Peromyscus polionotus trissyllepsis)\n                      5-Year Review: Summary and Evaluation\n                      . Panama City, FL: 2007; US Fish and Wildlife Service, Southeast Region."},{"key":"bibr37-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198303000-00006"},{"key":"bibr38-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1002\/path.1969"},{"key":"bibr39-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1177\/030098589303000214"},{"key":"bibr40-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2007.12.004"},{"key":"bibr41-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21006"},{"key":"bibr42-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1038\/ng.454"},{"key":"bibr43-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1016\/0248-4900(94)90021-3"},{"key":"bibr44-0300985815575051","doi-asserted-by":"publisher","DOI":"10.1177\/019262339101900406"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985815575051","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300985815575051","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985815575051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:55:45Z","timestamp":1777661745000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300985815575051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,19]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1177\/0300985815575051"],"URL":"https:\/\/doi.org\/10.1177\/0300985815575051","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,19]]}}}