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Animal models of skeletal metastases are essential to improve the understanding of the molecular pathways of cancer metastasis and growth in bone and to develop new therapies to inhibit and prevent bone metastases. The ideal animal model should be clinically relevant, reproducible, and representative of human disease. Currently, an ideal model does not exist; however, understanding the strengths and weaknesses of the available models will lead to proper study design and successful cancer research. This review provides an overview of the current in vivo animal models used in the study of skeletal metastases or local tumor invasion into bone and focuses on mammary and prostate cancer, lymphoma, multiple myeloma, head and neck squamous cell carcinoma, and miscellaneous tumors that metastasize to bone.<\/jats:p>","DOI":"10.1177\/0300985815586223","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T22:30:39Z","timestamp":1432852239000},"page":"827-841","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":140,"title":["Animal Models of Bone Metastasis"],"prefix":"10.1177","volume":"52","author":[{"given":"J. K.","family":"Simmons","sequence":"first","affiliation":[{"name":"Department of Veterinary Biosciences, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"B. 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