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Affected kittens typically developed rapidly progressive and marked generalized lymphadenopathy, moderate splenomegaly, and regenerative and likely hemolytic anemia from 6 weeks of age. Microscopic findings were suggestive of multicentric T-cell lymphoma, but additional testing revealed a polyclonal population of CD3+\/CD4\u2013\/CD8\u2013 \u201cdouble negative\u201d T cells (DNT cells). This is a novel disease presentation with similarities to the human disorder autoimmune lymphoproliferative syndrome (ALPS), a rare inherited disease causing lymphoproliferation and variable manifestations of autoimmunity. The human disease is most commonly due to the presence of Fas gene mutations causing defective lymphocyte apoptosis, and further investigations of both the mode of inheritance and genetic basis for disease in affected cats are currently in progress.<\/jats:p>","DOI":"10.1177\/0300985815586224","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T00:06:53Z","timestamp":1433376413000},"page":"1176-1182","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["A Novel and Likely Inherited Lymphoproliferative Disease in British Shorthair Kittens"],"prefix":"10.1177","volume":"52","author":[{"given":"D.","family":"Aberdein","sequence":"first","affiliation":[{"name":"Department of Pathobiology, Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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