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The prospect of a significant increase in the global elderly population within the next decades has led to the emergence of \u201cgeroscience,\u201d which aims at elucidating the molecular mechanisms involved in aging. Progeroid mouse models are frequently used in geroscience as they provide insight into the molecular mechanisms that are involved in the highly complex process of natural aging. This review provides an overview of the most commonly reported nonneoplastic macroscopic and microscopic pathologic findings in progeroid mouse models (eg, osteoporosis, osteoarthritis, degenerative joint disease, intervertebral disc degeneration, kyphosis, sarcopenia, cutaneous atrophy, wound healing, hair loss, alopecia, lymphoid atrophy, cataract, corneal endothelial dystrophy, retinal degenerative diseases, and vascular remodeling). Furthermore, several shortcomings in pathologic analysis and descriptions of these models are discussed. Progeroid mouse models are valuable models for aging, but thorough knowledge of both the mouse strain background and the progeria-related phenotype is required to guide interpretation and translation of the pathology data.<\/jats:p>","DOI":"10.1177\/0300985815625169","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T00:40:15Z","timestamp":1455151215000},"page":"366-389","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":103,"title":["Pathology of Mouse Models of Accelerated Aging"],"prefix":"10.1177","volume":"53","author":[{"given":"L.","family":"Harkema","sequence":"first","affiliation":[{"name":"Dutch Molecular Pathology Center, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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