{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T14:49:25Z","timestamp":1783003765755,"version":"3.54.5"},"reference-count":53,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,8,20]],"date-time":"2016-08-20T00:00:00Z","timestamp":1471651200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Spontaneous age-related lesions of laboratory rabbits are not well documented in the contemporary scientific literature. A retrospective study of diagnostic necropsies of 36 rabbits &gt;2 years of age found a number of common lung lesions. Fibromuscular intimal hyperplasia affected medium and to a lesser extent large pulmonary arteries and was present to a variable extent in all 36 rabbits &gt;2 years of age. The lesions were characterized by fragmentation and\/or reduplication of the internal elastic lamina (IEL), proliferation of smoothelin+\/alpha-smooth muscle actin (\u03b1-SMA)+\/vimentin\u2212 smooth muscle cells and fewer smoothelin\u2212\/\u03b1-SMA+\/vimentin+ myofibroblasts, and intimal deposition of collagen without thrombosis, embolism, or evidence of pulmonary hypertension. Pulmonary emphysema, present in 30\/36 rabbits, was characterized by the loss of alveolar septa; most affected rabbits did not have clinical signs of respiratory disease. In 8\/13 rabbits of the inbred EIII\/JC audiogenic strain, we identified a unique syndrome of granulomatous pneumonia containing hyaline brown to gray, globular to ring-like acellular material that was Alcian blue and periodic acid-Schiff positive. The material was immunoreactive for surfactant protein-A and had the ultrastructural appearance of multilamellar vesicles, suggesting a genetic defect in surfactant metabolism. Additionally, we found small benign primary lung tumors (fibropapillomas, 5 rabbits) not previously described. Other findings included heterotopic bone (5 rabbits), subacute to chronic suppurative bronchopneumonia, pyogranulomatous pneumonia with plant material, and pulmonary artifacts from barbiturate euthanasia solution.<\/jats:p>","DOI":"10.1177\/0300985816658102","type":"journal-article","created":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T22:53:09Z","timestamp":1470783189000},"page":"178-187","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Spontaneous Lung Lesions in Aging Laboratory Rabbits (\n                    <i>Oryctolagus cuniculus<\/i>\n                    )"],"prefix":"10.1177","volume":"54","author":[{"given":"T. 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