{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:26:49Z","timestamp":1777919209505,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T00:00:00Z","timestamp":1481673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>The aim of this study was to elucidate the cause of a neurological syndrome characterized by stridor in adult goats with clinical signs of copper deficiency. The main clinical signs consisted of apathy, emaciation, pale mucous membranes, mucous nasal discharge, dyspnea, severe achromotrichia, diffuse alopecia, torpor, ataxia, and stridor. When the goats were forced to move, the stridor increased. In a herd of 194 Toggenburg goats, 10 adult goats with clinical signs of copper deficiency were removed from the herd and divided into 2 groups: group 1, which consisted of 4 nannies and 1 buck with stridor, and group 2, which consisted of 4 nannies and 1 buck without stridor. Group 3, used as a control, consisted of 5 adult goats from another flock without any clinical signs of disease. The mean serum copper concentrations were 1.3 \u00b1 0.3 \u03bcmol\/L in group 1, 8.1 \u00b1 1.1 \u03bcmol\/L in group 2, and 11.3 \u00b1 2.2 \u03bcmol\/L in group 3. The mean serum iron concentrations were 42.3 \u00b1 14.2 \u03bcmol\/L in group 1, 39.1 \u00b1 8.2 \u03bcmol\/L in group 2, and 20.6 \u00b1 6.1 \u03bcmol\/L in group 3. The main histological lesions in goats from group 1 were axonal degeneration of the recurrent laryngeal nerves and atrophy of the muscles of vocal folds and of the dorsal cricoarytenoid and right and left cricothyroid muscles. Goats with ataxia had neuronal degeneration and necrosis of cerebellar Purkinje cells and of the cranial cervical ganglion. We concluded that the stridor was caused by axonal degeneration of the recurrent laryngeal nerves due to the severe copper deficiency.<\/jats:p>","DOI":"10.1177\/0300985816681410","type":"journal-article","created":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T19:05:21Z","timestamp":1497639921000},"page":"676-682","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Laryngeal Neuropathy in Adult Goats With Copper Deficiency"],"prefix":"10.1177","volume":"54","author":[{"given":"R. F. 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