{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:33:48Z","timestamp":1787502828027,"version":"build-2736575974"},"reference-count":13,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T00:00:00Z","timestamp":1482364800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Primary hypoadrenocorticism, or Addison\u2019s disease, is an autoimmune condition common in certain dog breeds that leads to the destruction of the adrenal cortex and a clinical syndrome involving anorexia, gastrointestinal upset, and electrolyte imbalances. Previous studies have demonstrated that this destruction is strongly associated with lymphocytic-plasmacytic inflammation and that the lymphocytes are primarily T cells. In this study, we used both immunohistochemistry and in situ hybridization to characterize the T-cell subtypes involved. We collected postmortem specimens of 5 dogs with primary hypoadrenocorticism and 2 control dogs and, using the aforementioned techniques, showed that the lymphocytes are primarily CD4+ rather than CD8+. These findings have important implications for improving our understanding of the pathogenesis and in searching for the underlying causative genetic polymorphisms.<\/jats:p>","DOI":"10.1177\/0300985816684914","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T21:15:24Z","timestamp":1513631724000},"page":"177-181","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Lymphocyte Subsets in the Adrenal Glands of Dogs With Primary Hypoadrenocorticism"],"prefix":"10.1177","volume":"55","author":[{"given":"S. G.","family":"Friedenberg","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA"},{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. L.","family":"Brown","sequence":"additional","affiliation":[{"name":"WIL Research (a Charles River Company), Hillsborough, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. M.","family":"Meurs","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. McHugh","family":"Law","sequence":"additional","affiliation":[{"name":"Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,12,22]]},"reference":[{"key":"bibr1-0300985816684914","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2015.01.001"},{"key":"bibr2-0300985816684914","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143458"},{"key":"bibr3-0300985816684914","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9975(05)80007-6"},{"key":"bibr4-0300985816684914","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2010.12.015"},{"key":"bibr5-0300985816684914","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2012.11.242"},{"key":"bibr6-0300985816684914","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2014.09.016"},{"issue":"2","key":"bibr7-0300985816684914","first-page":"353","volume":"29","author":"Hadlow WJ","year":"1953","journal-title":"Am J Pathol"},{"key":"bibr8-0300985816684914","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2010.01440.x"},{"key":"bibr9-0300985816684914","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-013-2442-0"},{"key":"bibr10-0300985816684914","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120994"},{"key":"bibr11-0300985816684914","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-013-0680-2"},{"key":"bibr12-0300985816684914","first-page":"786","volume":"22","author":"Schaer M","year":"1986","journal-title":"J Am Anim Hosp Assoc"},{"key":"bibr13-0300985816684914","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2014.10.001"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985816684914","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300985816684914","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985816684914","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:57:30Z","timestamp":1777661850000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300985816684914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,22]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1177\/0300985816684914"],"URL":"https:\/\/doi.org\/10.1177\/0300985816684914","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,22]]}}}