{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:06:30Z","timestamp":1787018790189,"version":"build-2736575974"},"reference-count":39,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T00:00:00Z","timestamp":1491436800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>Lymphoma has been described in individual cases for goats but not systematically characterized in a larger cohort. This study aimed to subtype caprine lymphoma based on topographic and subgross distribution, immunophenotype, and cellular morphology following the World Health Organization classification system for hematopoietic tumors in domestic animals. Fifteen caprine lymphoma cases were assessed with 6 submitted as biopsy and 9 for postmortem examination. Goats were predominantly young adult (median 3 years) and dwarf breeds (Pygmy and Pygora). The sexes were similarly represented. Nuclear size was measured relative to red blood cells (RBCs) and then adjusted for species-specific differences and designated small (&lt;3\u00d7 RBCs), intermediate (3\u20134\u00d7 RBCs), or large (&gt;4\u00d7 RBCs). Using immunohistochemistry, 11 of 15 (73%) goats had T-cell lymphoma (TCL; CD3 positive, CD79\u03b1 negative) and 4 of 15 (27%) had B-cell lymphoma (BCL; CD79\u03b1 positive, CD3 negative). A multicentric distribution was most common. TCL generally involved the thoracic cavity and\/or neck, suggestive of thymic origin or homing. TCLs were further classified as lymphoblastic lymphomas (3\/11; 27%), large granular lymphocyte lymphoma (1\/11; 9%), diffuse small lymphocytic lymphomas (3\/11; 27%), or peripheral\/mature T-cell lymphoma (PTCL) not otherwise specified (4\/11 [36%], of which 3 were high grade and 1 intermediate grade). In 1 goat with PTCL, lymph nodes had either paracortical expansion or diffuse infiltrates suggesting transition from nodular to diffuse PTLC. BCLs were classified as diffuse large B-cell lymphoma (2\/4; 50%) or B-cell lymphocytic lymphoma intermediate type (2\/4; 50%). In contrast to dogs and horses, lymphomas in goats are predominantly TCL and frequently involve the mediastinum.<\/jats:p>","DOI":"10.1177\/0300985817699859","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T07:18:54Z","timestamp":1491463134000},"page":"611-619","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Lymphoma Classification in Goats"],"prefix":"10.1177","volume":"54","author":[{"given":"Patti K.","family":"Kiser","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Oregon Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane V.","family":"L\u00f6hr","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Oregon Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,4,6]]},"reference":[{"key":"bibr1-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1177\/1040638712471059"},{"key":"bibr2-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/429495"},{"key":"bibr3-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1081\/CNV-120005924"},{"key":"bibr4-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.02.006"},{"issue":"3","key":"bibr5-0300985817699859","first-page":"199","volume":"50","author":"Bastianello SS","year":"1983","journal-title":"Onderstepoort J Vet Res"},{"key":"bibr6-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.11-6-590"},{"key":"bibr7-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1963.tb13426.x"},{"key":"bibr8-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1024\/0036-7281\/a000166"},{"issue":"2","key":"bibr9-0300985817699859","first-page":"154","volume":"50","author":"Carter RF","year":"1986","journal-title":"Can J Vet Res"},{"issue":"4","key":"bibr10-0300985817699859","first-page":"S190","volume":"8","author":"Craig DR","year":"1986","journal-title":"Compend Cont Educ Pract Vet"},{"issue":"7","key":"bibr11-0300985817699859","first-page":"649","volume":"49","author":"Damodaran S","year":"1972","journal-title":"Indian Vet J"},{"key":"bibr12-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1136\/vr.117.11.276"},{"issue":"6","key":"bibr13-0300985817699859","first-page":"383","volume":"38","author":"DiGrassie WA","year":"1997","journal-title":"Can Vet J"},{"key":"bibr14-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1177\/0300985812451603"},{"key":"bibr15-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X13516621"},{"key":"bibr16-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-1-92"},{"key":"bibr17-0300985817699859","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.4518"},{"key":"bibr18-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9846(17)30055-1"},{"key":"bibr19-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1999.tb12085.x"},{"key":"bibr20-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1136\/vr.143.2.51"},{"key":"bibr21-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1024\/0036-7281.146.11.523"},{"key":"bibr22-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1136\/vr.114.7.170"},{"issue":"6","key":"bibr23-0300985817699859","first-page":"E21","volume":"48","author":"Howerth E","year":"2011","journal-title":"Vet Pathol"},{"key":"bibr24-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62569-2"},{"key":"bibr25-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1177\/0300985812471544"},{"key":"bibr26-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1354\/vp.46-2-288"},{"key":"bibr27-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000090"},{"key":"bibr28-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0b013e31826b1232"},{"key":"bibr29-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1998.tb01644.x"},{"key":"bibr30-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0442.1994.tb00150.x"},{"key":"bibr31-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1998.tb02134.x"},{"issue":"12","key":"bibr32-0300985817699859","first-page":"1350","volume":"52","author":"Valentine BA","year":"2011","journal-title":"Can Vet J"},{"key":"bibr33-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1177\/104063870001200401"},{"key":"bibr34-0300985817699859","volume-title":"Histological Classification of Hematopoietic Tumors of Domestic Animals. World Health Organization International Classification of Tumors in Domestic Animals","author":"Valli VE","year":"2002"},{"key":"bibr35-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1002\/9780470344545"},{"key":"bibr36-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810379428"},{"key":"bibr37-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1177\/0300985813478210"},{"key":"bibr38-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2009.00201.x"},{"key":"bibr39-0300985817699859","doi-asserted-by":"publisher","DOI":"10.1177\/030098587601300610"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985817699859","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300985817699859","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985817699859","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:57:47Z","timestamp":1777661867000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300985817699859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,6]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1177\/0300985817699859"],"URL":"https:\/\/doi.org\/10.1177\/0300985817699859","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,6]]}}}