{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T21:07:37Z","timestamp":1785359257306,"version":"3.55.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T00:00:00Z","timestamp":1498521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Metallosis is the accumulation of metallic debris in soft tissues resulting from wear following total joint replacement. A dog was evaluated for lameness 4 years after total hip arthroplasty using a titanium alloy and cobalt chromium total hip system. Radiographs revealed severe acetabular component wear, implant-bone interface deterioration, and peri-acetabular osteolysis. During surgical revision, black periarticular tissue surrounded the implants. Histologically, there was fibrosis and granulomatous inflammation with abundant, intra- and extracellular, black, granular material and smaller amounts of clear punctate to acicular material. Laser capture microdissection followed by x-ray fluorescence microscopy indicated the material contained large amounts of titanium with smaller amounts of vanadium, cobalt, and chromium, confirming the diagnosis of metallosis. The clear material was birefringent under cross-polarized light, stained positive with Oil-Red-O, and thus was consistent with polyethylene. Metallosis exhibits characteristic gross and histologic lesions and is a differential diagnosis for aseptic loosening of hip implants.<\/jats:p>","DOI":"10.1177\/0300985817716261","type":"journal-article","created":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T03:08:58Z","timestamp":1498532938000},"page":"828-831","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Metallosis in a Dog as a Long-Term Complication Following Total Hip Arthroplasty"],"prefix":"10.1177","volume":"54","author":[{"given":"Mallory J.","family":"DiVincenzo","sequence":"first","affiliation":[{"name":"Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA, USA"},{"name":"Current affiliation: College of Veterinary Medicine at The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galit H.","family":"Frydman","sequence":"additional","affiliation":[{"name":"Division of Comparative Medicine, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA"},{"name":"Division of Surgery, Innovation & Bioengineering, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Kowaleski","sequence":"additional","affiliation":[{"name":"Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles R.","family":"Vanderburg","sequence":"additional","affiliation":[{"name":"Advanced Tissue Resource Center, Massachusetts General Hospital Institute for Neurodegenerative Disease, Charlestown, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Lai","sequence":"additional","affiliation":[{"name":"X-ray Science Division, Argonne National Laboratory, US Department of Energy, Argonne, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trisha J.","family":"Oura","sequence":"additional","affiliation":[{"name":"Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel H.","family":"Jennings","sequence":"additional","affiliation":[{"name":"Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,6,27]]},"reference":[{"key":"bibr1-0300985817716261","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v6.i2.172"},{"key":"bibr2-0300985817716261","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2014.944977"},{"issue":"2","key":"bibr3-0300985817716261","first-page":"E18","volume":"37","author":"Cipriano CA","year":"2008","journal-title":"Am J Orthop"},{"key":"bibr4-0300985817716261","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-12-74"},{"key":"bibr5-0300985817716261","doi-asserted-by":"publisher","DOI":"10.3109\/17453679408993734"},{"key":"bibr6-0300985817716261","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2005.12.011"},{"key":"bibr7-0300985817716261","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v5.i5.660"},{"key":"bibr8-0300985817716261","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.12492"},{"key":"bibr9-0300985817716261","doi-asserted-by":"publisher","DOI":"10.1002\/jab.770040202"},{"key":"bibr10-0300985817716261","doi-asserted-by":"publisher","DOI":"10.3415\/VCOT-16-02-0028"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985817716261","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300985817716261","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985817716261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:58:01Z","timestamp":1777661881000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300985817716261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,27]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1177\/0300985817716261"],"URL":"https:\/\/doi.org\/10.1177\/0300985817716261","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,27]]}}}