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In this study, the authors investigated the pathogenesis of FeHV-1-associated pneumonia, comparing natural cases with viral infection of tracheal ring and cell cultures in vitro, using histology, immunohistology, double immunofluorescence, and transmission electron microscopy as investigative tools. The results confirm that FeHV-1 targets both respiratory epithelial cells and pneumocytes and indicate that FeHV-1 pneumonia is the consequence of continuous cell-to-cell viral spread from the upper airways via the trachea into the lungs. They provide strong evidence that FeHV-1\u2013infected cells die primarily via apoptosis, following loss of cell-to-cell contact, rounding, and detachment. However, virus-induced lesions in vivo are dominated by marked neutrophil infiltration and extensive necrosis with less prominent apoptosis; in the airways, the tissue necrosis can extend into the submucosa. The necrosis appears to result from virus-induced neutrophil influx and release of proteolytic enzymes, such as matrix metalloproteinase-9, from the neutrophils.<\/jats:p>","DOI":"10.1177\/0300985817720982","type":"journal-article","created":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T06:20:13Z","timestamp":1502864413000},"page":"922-932","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Feline Herpesvirus Pneumonia: Investigations Into the Pathogenesis"],"prefix":"10.1177","volume":"54","author":[{"given":"Josep Maria","family":"Monne Rodriguez","sequence":"first","affiliation":[{"name":"Division of Pathology, School of Veterinary Science, University of Liverpool, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail","family":"Leeming","sequence":"additional","affiliation":[{"name":"Division of Pathology, School of Veterinary Science, University of Liverpool, 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