{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:28:43Z","timestamp":1791772123907,"version":"4.3.4"},"reference-count":53,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T00:00:00Z","timestamp":1516060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00c3\u00adfico e Tecnol\u00c3\u00b3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>\n                    Mast cell tumor (MCT) is a frequent cutaneous neoplasm in dogs that is heterogeneous in clinical presentation and biological behavior, with a variable potential for recurrence and metastasis. Accurate prediction of clinical outcomes has been challenging. The study objective was to develop a system for classification of canine MCT according to the mortality risk based on individual assessment of clinical, histologic, immunohistochemical, and molecular features. The study included 149 dogs with a histologic diagnosis of cutaneous or subcutaneous MCT. By univariate analysis, MCT metastasis and related death was significantly associated with clinical stage ( P &lt; .0001, r\n                    <jats:sub>P<\/jats:sub>\n                    = \u20130.610), history of tumor recurrence ( P &lt; .0001, r\n                    <jats:sub>P<\/jats:sub>\n                    = \u20130.550), Patnaik ( P &lt; .0001, r\n                    <jats:sub>P<\/jats:sub>\n                    = \u20130.380) and Kiupel grades ( P &lt; .0001, r\n                    <jats:sub>P<\/jats:sub>\n                    = \u20130.500), predominant organization of neoplastic cells ( P &lt; .0001, r\n                    <jats:sub>P<\/jats:sub>\n                    = \u20130.452), mitotic count ( P &lt; .0001, r\n                    <jats:sub>P<\/jats:sub>\n                    = \u20130.325), Ki-67 labeling index ( P &lt; .0001, r\n                    <jats:sub>P<\/jats:sub>\n                    = \u20130.414), KITr pattern ( P = .02, r\n                    <jats:sub>P<\/jats:sub>\n                    = 0.207), and c-KIT mutational status ( P &lt; .0001, r\n                    <jats:sub>P<\/jats:sub>\n                    = \u20130.356). By multivariate analysis with Cox proportional hazard model, only 2 features were independent predictors of overall survival: an amendment of the World Health Organization clinical staging system (hazard ratio [95% CI]: 1.824 [1.210-4.481]; P = .01) and a history of tumor recurrence (hazard ratio [95% CI]: 9.250 [2.158-23.268]; P &lt; .001]. From these results, we propose an amendment of the WHO staging system, a method of risk analysis, and a suggested approach to clinical and laboratory evaluation of dogs with cutaneous MCT.\n                  <\/jats:p>","DOI":"10.1177\/0300985817747325","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T22:24:26Z","timestamp":1516141466000},"page":"212-223","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":98,"title":["Assessment of Canine Mast Cell Tumor Mortality Risk Based on Clinical, Histologic, Immunohistochemical, and Molecular Features"],"prefix":"10.1177","volume":"55","author":[{"given":"Rodrigo S.","family":"Horta","sequence":"first","affiliation":[{"name":"Universidade Vila Velha, Vila Velha, ES, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gleidice E.","family":"Lavalle","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinics and Surgery, Veterinary School, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidianne N.","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Laboratory of Comparative Pathology, Biological Science Institute, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayara C. 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