{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:06:28Z","timestamp":1787018788968,"version":"build-2736575974"},"reference-count":14,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T00:00:00Z","timestamp":1518566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>Multiple myeloma oncogene 1\/interferon regulatory factor 4 (MUM1\/IRF-4) immunohistochemistry (IHC) is mainly used for diagnostic confirmation of plasma cell tumors (PCTs) in dogs and cats. This article describes MUM1\/IRF-4 IHC expression in 20 cases of canine cutaneous histiocytoma (CH) and compares it with 10 cutaneous or mucocutaneous PCTs and 5 cutaneous histiocytic sarcomas (HSs) submitted to the same IHC protocol. All histiocytomas had strong nuclear and variable cytoplasmic immunolabeling for MUM1\/IRF-4, whereas all PCTs had strong nuclear and moderate cytoplasmic immunolabeling for MUM1\/IRF-4. No MUM1\/IRF-4 immunolabeling was detected in the HSs. Although not typically a diagnostic challenge, MUM1\/IRF-4 expression may have to be used with caution or in conjunction with additional immunomarkers to differentiate among poorly differentiated round cell tumors, especially when a histiocytic or plasma cell origin is suspected.<\/jats:p>","DOI":"10.1177\/0300985818759770","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:57:59Z","timestamp":1518656279000},"page":"517-520","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Immunohistochemical Labeling of Multiple Myeloma Oncogene 1\/Interferon Regulatory Factor 4 (MUM1\/IRF-4) in Canine Cutaneous Histiocytoma"],"prefix":"10.1177","volume":"55","author":[{"given":"Justin M.","family":"Stilwell","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Georgia College of Veterinary Medicine, Athens, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Rissi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Athens Veterinary Diagnostic Laboratory, University of Georgia College of Veterinary Medicine, Athens, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,2,14]]},"reference":[{"key":"bibr1-0300985818759770","doi-asserted-by":"publisher","DOI":"10.1354\/vp.42-4-437"},{"key":"bibr2-0300985818759770","doi-asserted-by":"publisher","DOI":"10.1104\/pp.104.900198"},{"key":"bibr3-0300985818759770","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.10.6570"},{"issue":"5","key":"bibr4-0300985818759770","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.4049\/jimmunol.163.5.2713","volume":"163","author":"Marecki S","year":"1999","journal-title":"J Immunol"},{"key":"bibr5-0300985818759770","doi-asserted-by":"publisher","DOI":"10.1177\/0300985813510413"},{"key":"bibr6-0300985818759770","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880373"},{"issue":"6","key":"bibr7-0300985818759770","doi-asserted-by":"crossref","first-page":"803","DOI":"10.2460\/javma.1989.194.06.803","volume":"194","author":"Rakich PM","year":"1989","journal-title":"J Am Vet Med Assoc"},{"key":"bibr8-0300985818759770","first-page":"44","volume-title":"Tumors of Domestic Animals","author":"Ramos-Vara JA","year":"2017","edition":"5"},{"key":"bibr9-0300985818759770","doi-asserted-by":"publisher","DOI":"10.1177\/0300985811398251"},{"key":"bibr10-0300985818759770","doi-asserted-by":"publisher","DOI":"10.1354\/vp.44-6-875"},{"key":"bibr11-0300985818759770","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.12.4274"},{"key":"bibr12-0300985818759770","doi-asserted-by":"publisher","DOI":"10.1177\/030098588702400604"},{"key":"bibr13-0300985818759770","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402139101"},{"key":"bibr14-0300985818759770","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3990"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985818759770","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300985818759770","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985818759770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:58:34Z","timestamp":1777661914000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300985818759770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,14]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1177\/0300985818759770"],"URL":"https:\/\/doi.org\/10.1177\/0300985818759770","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,14]]}}}