{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:41:03Z","timestamp":1787319663665,"version":"build-2736575974"},"reference-count":11,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T00:00:00Z","timestamp":1534809600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>Portuguese Water Dog breeders and veterinary ophthalmologists recognize microphthalmia with multiple congenital ocular anomalies. Fifteen Portuguese Water Dog puppies (&lt;8 weeks of age; 8 females, 7 males) and 1 adult (5 years old; castrated male) with microphthalmia were examined. The 2 most common abnormalities were microphthalmia (31\/32 eyes; 97%) and lens abnormality (congenital cataract or aphakia; 32\/32 eyes; 100%). Other common histologic lesions included lack of both a ciliary cleft and trabecular meshwork (15\/32 eyes; 47%) and abnormal relationship of anterior segment structures (15\/32 eyes; 47%). Many of the observed lesions were similar to those described in various types of anterior segment dysgenesis in humans. Our findings define the histologic lesions in affected Portuguese Water Dogs and suggest a genetic defect that causes anterior segment malformation early in development.<\/jats:p>","DOI":"10.1177\/0300985818794248","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T01:17:11Z","timestamp":1534900631000},"page":"269-273","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Microphthalmia With Multiple Anterior Segment Defects in Portuguese Water Dogs"],"prefix":"10.1177","volume":"56","author":[{"given":"Gillian C.","family":"Shaw","sequence":"first","affiliation":[{"name":"The Comparative Ocular Pathology Laboratory of Wisconsin, University of Wisconsin School of Veterinary Medicine, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May P. Y.","family":"Tse","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Section of Anatomic Pathology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Section of Anatomic Pathology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,8,21]]},"reference":[{"issue":"12","key":"bibr1-0300985818794248","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.2460\/ajvr.1972.33.12.2399","volume":"33","author":"Aguirre GD","year":"1972","journal-title":"Am J Vet Res"},{"key":"bibr2-0300985818794248","doi-asserted-by":"publisher","DOI":"10.1136\/vr.85.9.242"},{"key":"bibr3-0300985818794248","first-page":"3","volume-title":"Veterinary Ophthalmology","author":"Cook CS","year":"2013","edition":"5"},{"key":"bibr4-0300985818794248","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2006.02.006"},{"key":"bibr5-0300985818794248","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/25.5.1009"},{"key":"bibr6-0300985818794248","doi-asserted-by":"publisher","DOI":"10.1186\/2052-6687-1-3"},{"key":"bibr7-0300985818794248","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.07.039"},{"key":"bibr8-0300985818794248","first-page":"147","volume-title":"Essentials of Veterinary Ophthalmology","author":"Spiess BM","year":"2014","edition":"3"},{"key":"bibr9-0300985818794248","doi-asserted-by":"publisher","DOI":"10.1053\/jcpa.2001.0512"},{"key":"bibr10-0300985818794248","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.30.8.664"},{"key":"bibr11-0300985818794248","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1989.01070020697031"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985818794248","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300985818794248","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985818794248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:59:02Z","timestamp":1777661942000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300985818794248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,21]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1177\/0300985818794248"],"URL":"https:\/\/doi.org\/10.1177\/0300985818794248","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,21]]}}}