{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:47:25Z","timestamp":1791474445787,"version":"4.3.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T00:00:00Z","timestamp":1536537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Ovine herpesvirus 2 (OvHV-2) is one of the gammaherpesviruses in the genus Macavirus that can cause malignant catarrhal fever (MCF) in ungulates. Sheep are the adapted host for OvHV-2 and it is generally assumed that infection is not associated with disease in this species. However, cases of \u201cpolyarteritis nodosa\u201d or idiopathic systemic necrotizing vasculitis reported in sheep are similar to vascular lesions in clinically susceptible species with MCF. Using a recently developed in situ hybridization (ISH) method, we were able to identify OvHV-2 nucleic acids within lesions and correlate the viral distribution with systemic necrotizing vasculitis in 9 sheep, including both naturally and experimentally OvHV-2\u2013infected animals. ISH, combined with polymerase chain reaction and histology, identify OvHV-2 as the likely agent responsible for sporadic, MCF-like vascular disease in sheep.<\/jats:p>","DOI":"10.1177\/0300985818795166","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T22:49:21Z","timestamp":1536619761000},"page":"87-92","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Systemic Necrotizing Vasculitis in Sheep Is Associated With Ovine Herpesvirus 2"],"prefix":"10.1177","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6593-9607","authenticated-orcid":false,"given":"Patricia A.","family":"Pesavento","sequence":"first","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul B.","family":"Dange","sequence":"additional","affiliation":[{"name":"California Animal Health and Food Safety Laboratory System, UC Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Carmen","family":"Ferreras","sequence":"additional","affiliation":[{"name":"Dpto. Sanidad Animal, Instituto de Ganader\u00eda de Monta\u00f1a (Uninversidad de Le\u00f3n-CSIC) Facultad de Veterinaria, Universidad de Le\u00f3n Campus de Vegazana, Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akbar","family":"Dasjerdi","sequence":"additional","affiliation":[{"name":"Animal and Plant Health Agency-Weybridge, Addlestone, Surrey, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Dpto. Sanidad Animal, Instituto de Ganader\u00eda de Monta\u00f1a (Uninversidad de Le\u00f3n-CSIC) Facultad de Veterinaria, Universidad de Le\u00f3n Campus de Vegazana, Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"LaRoca","sequence":"additional","affiliation":[{"name":"Animal and Plant Health Agency-Weybridge, Addlestone, Surrey, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio Benavides","family":"Silv\u00e1n","sequence":"additional","affiliation":[{"name":"Dpto. 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