{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T18:21:08Z","timestamp":1781288468722,"version":"3.54.1"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T00:00:00Z","timestamp":1550361600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>An 11-year-old castrated male Chihuahua dog was presented with complaints of polyuria, polydipsia, abdominal enlargement, and alopecia. Hyperadrenocorticism was diagnosed on the basis of clinical signs, blood tests, adrenocorticotropin-stimulation test results, and an elevated serum adrenocorticotropin concentration. Contrast-enhanced magnetic resonance imaging showed that the pituitary gland was enlarged, compatible with a pituitary macroadenoma. Pituitary-dependent hyperadrenocorticism was suspected, and transsphenoidal hypophysectomy was thus performed for complete resection of the tumor. After surgery, the serum adrenocorticotropin concentration normalized and the hyperadrenocorticism resolved. Histological and immunocytochemical analyses revealed a benign tumor composed of mature neuronal cells and glial cells, suggestive of a ganglioglioma with immunolabeling for adrenocorticotropin. Careful analysis of the resected tumor revealed no pituitary adenoma tissue. The clinical and histopathologic findings indicated that the ganglioglioma was directly responsible for the hyperadrenocorticism. This is the first case of hyperadrenocorticism caused by a ganglioglioma in a dog.<\/jats:p>","DOI":"10.1177\/0300985819829530","type":"journal-article","created":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T05:39:02Z","timestamp":1550468342000},"page":"609-613","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Hyperadrenocorticism Caused by a Pituitary Ganglioglioma in a Dog"],"prefix":"10.1177","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8518-646X","authenticated-orcid":false,"given":"Hirokazu","family":"Ishino","sequence":"first","affiliation":[{"name":"Laboratory of Small Animal Surgery 1, School of Veterinary Medicine, Kitasato University, Towada, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Takekoshi","sequence":"additional","affiliation":[{"name":"Division of Host Defense Mechanism, Department of Cell Biology, Tokai University School of Medicine, Isehara-shi, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9646-6785","authenticated-orcid":false,"given":"Takahiro","family":"Teshima","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Medicine, Faculty of Veterinary Medicine, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino-shi, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2302-799X","authenticated-orcid":false,"given":"Kazuyuki","family":"Uchida","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwao","family":"Sakonju","sequence":"additional","affiliation":[{"name":"Laboratory of Small Animal Surgery 1, School of Veterinary Medicine, Kitasato University, Towada, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Hara","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Surgery, Department of Veterinary Clinical Medicine, Faculty of Veterinary Medicine, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino-shi, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,2,17]]},"reference":[{"key":"bibr1-0300985819829530","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-3-311"},{"key":"bibr2-0300985819829530","doi-asserted-by":"publisher","DOI":"10.1111\/rda.12821"},{"key":"bibr3-0300985819829530","doi-asserted-by":"publisher","DOI":"10.17221\/7623-VETMED"},{"key":"bibr4-0300985819829530","doi-asserted-by":"publisher","DOI":"10.1530\/JME-15-0323"},{"key":"bibr5-0300985819829530","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0185"},{"key":"bibr6-0300985819829530","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1999.tb13149.x"},{"key":"bibr7-0300985819829530","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2016.08.002"},{"key":"bibr8-0300985819829530","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-014-0595-4"},{"key":"bibr9-0300985819829530","first-page":"252","volume-title":"Canine and Feline Endocrinology and Reproduction","author":"Feldman EC","year":"2004","edition":"3"},{"key":"bibr10-0300985819829530","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2007.04.008"},{"key":"bibr11-0300985819829530","doi-asserted-by":"publisher","DOI":"10.1016\/j.domaniend.2004.11.001"},{"key":"bibr12-0300985819829530","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2016.02.024"},{"key":"bibr13-0300985819829530","first-page":"1","volume-title":"The WHO International Histological Classification of Tumors of Domestic Animals. 2nd series, vol 5","author":"Koestner A","year":"1999"},{"key":"bibr14-0300985819829530","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1520387"},{"key":"bibr15-0300985819829530","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-009-0190-2"},{"key":"bibr16-0300985819829530","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1998.tb00123.x"},{"key":"bibr17-0300985819829530","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.68.1"},{"key":"bibr18-0300985819829530","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.71.93"},{"key":"bibr19-0300985819829530","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.65.113"},{"key":"bibr20-0300985819829530","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2015.04.014"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985819829530","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300985819829530","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985819829530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:59:36Z","timestamp":1777661976000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300985819829530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,17]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1177\/0300985819829530"],"URL":"https:\/\/doi.org\/10.1177\/0300985819829530","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,17]]}}}