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An orthokeratotic, hyperkeratotic, acanthotic dermatitis developed in the C. bovis\u2013infected dep\/dep mice, which remained C. bovis PCR-positive for &gt;45 days prior to euthanasia as part of the program-wide C. bovis eradication effort. Since both affected strains of mice have altered skin homeostasis, immune status or the presence of hair may not alone be sufficient to explain strain susceptibility to C. bovis\u2013related cutaneous disease. In order to avoid invalidation of preclinical studies due to C. bovis infection, it may be necessary to isolate immunodeficient mouse strains, implement facililty-wide surveillance for C. bovis, and sterilize equipment with vaporized hydrogen peroxide.<\/jats:p>","DOI":"10.1177\/0300985820922219","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T06:50:13Z","timestamp":1588143013000},"page":"586-589","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Persistent\n                    <i>Corynebacterium bovis<\/i>\n                    Infectious Hyperkeratotic Dermatitis in Immunocompetent Epidermal-Mutant\n                    <i>dep\/dep<\/i>\n                    Mice"],"prefix":"10.1177","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2843-2097","authenticated-orcid":false,"given":"Emily L.","family":"Miedel","sequence":"first","affiliation":[{"name":"H. 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