{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T05:58:05Z","timestamp":1782626285401,"version":"3.54.5"},"reference-count":17,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T00:00:00Z","timestamp":1590451200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100008431","name":"Consejer\u00eda de Educaci\u00f3n, Junta de Castilla y Le\u00f3n","doi-asserted-by":"crossref","award":["LE253U13"],"award-info":[{"award-number":["LE253U13"]}],"id":[{"id":"10.13039\/501100008431","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>Early abortion in ovine toxoplasmosis has had limited investigation. This study evaluated the immune response in the placenta of sheep orally infected with Toxoplasma gondii and euthanized between 2 and 4 weeks postinfection. Toxoplasma infection of the placenta was only found at 4 weeks after infection. Parasitic debris in foci of necrosis were immunolabeled in the maternal caruncle, whereas well-preserved intracellular parasitic vacuole-like structures were found in trophoblasts of fetal cotyledon. Early abortions had increased macrophages in caruncular septa, whereas in later abortions the placentas containing the parasite had an increase of T lymphocytes and macrophages mainly in the fetal cotyledons. This study suggests that the immune response in both the fetal and maternal compartments of the placenta may contribute to the pathogenesis of ovine toxoplasmosis and that these responses differ between early and late presentations of the disease.<\/jats:p>","DOI":"10.1177\/0300985820923987","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T08:07:55Z","timestamp":1590480475000},"page":"545-549","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Macrophages and T Lymphocytes in the Ovine Placenta After Experimental Infection With\n                    <i>Toxoplasma gondii<\/i>"],"prefix":"10.1177","volume":"57","author":[{"given":"Pablo","family":"Casta\u00f1o","sequence":"first","affiliation":[{"name":"Instituto de Ganader\u00eda de Monta\u00f1a (CSIC-Universidad de Le\u00f3n), Grulleros, Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Fuertes","sequence":"additional","affiliation":[{"name":"Instituto de Ganader\u00eda de Monta\u00f1a (CSIC-Universidad de Le\u00f3n), Grulleros, Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4690-7770","authenticated-orcid":false,"given":"Miguel","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Instituto de Ganader\u00eda de Monta\u00f1a (CSIC-Universidad de Le\u00f3n), Grulleros, Le\u00f3n, Spain"},{"name":"Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de Le\u00f3n, Campus de Vegazana, Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Carmen","family":"Ferreras","sequence":"additional","affiliation":[{"name":"Instituto de Ganader\u00eda de Monta\u00f1a (CSIC-Universidad de Le\u00f3n), Grulleros, Le\u00f3n, Spain"},{"name":"Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de Le\u00f3n, Campus de Vegazana, Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Ferre","sequence":"additional","affiliation":[{"name":"Complutense University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Miguel","family":"Ortega-Mora","sequence":"additional","affiliation":[{"name":"Complutense University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valent\u00edn","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Instituto de Ganader\u00eda de Monta\u00f1a (CSIC-Universidad de Le\u00f3n), Grulleros, Le\u00f3n, Spain"},{"name":"Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de Le\u00f3n, Campus de Vegazana, Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9706-100X","authenticated-orcid":false,"given":"Julio","family":"Benavides","sequence":"additional","affiliation":[{"name":"Instituto de Ganader\u00eda de Monta\u00f1a (CSIC-Universidad de Le\u00f3n), Grulleros, Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,5,26]]},"reference":[{"key":"bibr1-0300985820923987","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2017.04.003"},{"key":"bibr2-0300985820923987","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(86)90052-6"},{"key":"bibr3-0300985820923987","doi-asserted-by":"publisher","DOI":"10.1186\/s13567-019-0681-8"},{"key":"bibr4-0300985820923987","doi-asserted-by":"publisher","DOI":"10.1186\/1297-9716-45-9"},{"key":"bibr5-0300985820923987","doi-asserted-by":"publisher","DOI":"10.1186\/s13567-016-0327-z"},{"key":"bibr6-0300985820923987","first-page":"279","volume-title":"Dellmann\u2019s Textbook of Veterinary Histology","author":"Dantzer V","year":"2006","edition":"6"},{"key":"bibr7-0300985820923987","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2005.05.010"},{"key":"bibr8-0300985820923987","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9975(05)80074-X"},{"key":"bibr9-0300985820923987","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-019-00552-7"},{"key":"bibr10-0300985820923987","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-019-3466-z"},{"key":"bibr11-0300985820923987","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830230520"},{"key":"bibr12-0300985820923987","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.02213.x"},{"issue":"1","key":"bibr13-0300985820923987","first-page":"55","volume":"50","author":"Pfaff AW","year":"2008","journal-title":"Parassitologia"},{"key":"bibr14-0300985820923987","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-54090-0_3"},{"key":"bibr15-0300985820923987","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01780-06"},{"key":"bibr16-0300985820923987","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000221"},{"key":"bibr17-0300985820923987","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.03025"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985820923987","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300985820923987","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985820923987","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:00:43Z","timestamp":1777662043000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300985820923987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,26]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1177\/0300985820923987"],"URL":"https:\/\/doi.org\/10.1177\/0300985820923987","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,26]]}}}