{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:52:00Z","timestamp":1785577920005,"version":"3.56.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>\n                    In a collection of 6 young binturongs ( Arctictis binturong), 3 presented with anorexia, lethargy, and footpad swelling diagnosed by surgical biopsy as calcinosis circumscripta. Despite supportive care over the next 4 years, affected binturongs had progressive weight loss, hyperphosphatemia, and hyperkalemia and developed large radiodense deposits in tissues adjacent to appendicular joints, thoracolumbar vertebrae, and the sternum. Two binturongs died and necropsies showed severe periarticular mineral deposition with fibrosis and granulomatous inflammation. Additionally, binturongs had mineralization of distal renal tubules, mineralization of the renal interstitium, and marked mineralization of the pulmonary interstitium and peribronchiolar smooth muscle. Foot biopsies from the surviving binturong were evaluated by spectroscopic microanalysis and were positive for hydroxyapatite, Ca\n                    <jats:sub>10<\/jats:sub>\n                    (PO\n                    <jats:sub>4<\/jats:sub>\n                    )\n                    <jats:sub>6<\/jats:sub>\n                    (OH)\n                    <jats:sub>2<\/jats:sub>\n                    . Periarticular and footpad mineralization in these binturongs is consistent with hydroxyapatite deposition disease, which is rarely described in humans and animals as a primary familial condition or a secondary condition often associated with renal injury.\n                  <\/jats:p>","DOI":"10.1177\/03009858211020669","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T05:12:30Z","timestamp":1622524350000},"page":"1147-1151","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Severe Hydroxyapatite Deposition Disease in Binturongs (Arctictis\n                    <i>binturong<\/i>\n                    )"],"prefix":"10.1177","volume":"58","author":[{"given":"Kazuya","family":"Takehana","sequence":"first","affiliation":[{"name":"Ichihara Elephant Kingdom Zoological Park, Ichihara, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1525-1166","authenticated-orcid":false,"given":"Anneke","family":"Moresco","sequence":"additional","affiliation":[{"name":"Reproductive Health Surveillance Program, Morrison, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"James G.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Saint Louis Zoo, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Tokyo Dental College, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Tokyo Dental College, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5952-4480","authenticated-orcid":false,"given":"Sushan","family":"Han","sequence":"additional","affiliation":[{"name":"Colorado State University, Fort Collins, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,6,1]]},"reference":[{"key":"bibr1-03009858211020669","doi-asserted-by":"publisher","DOI":"10.1177\/0300985813480511"},{"key":"bibr2-03009858211020669","first-page":"251","volume":"85","author":"Crapo C","year":"2002","journal-title":"J Dairy Sci"},{"key":"bibr3-03009858211020669","first-page":"516","volume-title":"Zoo and Wild Animal Medicine","author":"Denver M","year":"2003","edition":"5"},{"key":"bibr4-03009858211020669","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v2.i9.409"},{"key":"bibr5-03009858211020669","doi-asserted-by":"publisher","DOI":"10.1638\/2015-0008.1"},{"key":"bibr6-03009858211020669","doi-asserted-by":"publisher","DOI":"10.5625\/lar.2016.32.1.74"},{"key":"bibr7-03009858211020669","volume-title":"A retrospective evaluation of binturong (Arctictis binturong) morbidity and mortality under managed care in US institutions","author":"McFarland A"},{"key":"bibr8-03009858211020669","doi-asserted-by":"publisher","DOI":"10.1515\/mammalia-2015-0009"},{"key":"bibr9-03009858211020669","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0442.2004.00675.x"},{"key":"bibr10-03009858211020669","doi-asserted-by":"publisher","DOI":"10.1354\/vp.37-4-346"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03009858211020669","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03009858211020669","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03009858211020669","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:02:01Z","timestamp":1777662121000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03009858211020669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,1]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1177\/03009858211020669"],"URL":"https:\/\/doi.org\/10.1177\/03009858211020669","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,1]]}}}