{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T03:06:07Z","timestamp":1794539167640,"version":"4.9.1"},"reference-count":19,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["635408"],"award-info":[{"award-number":["635408"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>\n                    Johne\u2019s disease (JD) is a chronic granulomatous enteritis caused by Mycobacterium avium subsp. paratuberculosis (MAP). While it is generally accepted that MAP employs immune subversion mechanisms, aspects of the host-pathogen relationship are not fully understood. We sampled 3 ileal tissue sections from 17 naturally infected cattle ( n = 51 sections) to analyze differences in cell types, apoptosis, and phagocytic cells. Diffuse multibacillary (DM) was the most common lesion type ( n = 17) followed by diffuse intermediate (DI; n = 15). DM lesions had significantly greater proportion of Treg cells (CD3\n                    <jats:sup>+<\/jats:sup>\n                    FoxP3\n                    <jats:sup>+)<\/jats:sup>\n                    relative to all CD3\n                    <jats:sup>+<\/jats:sup>\n                    T cells as compared to DI forms ( P &lt; .05). CD68\n                    <jats:sup>+<\/jats:sup>\n                    individual cell size was significantly smaller in DM than in diffuse lymphocytic (DL) forms ( P &lt; .05). Area of caspase-3 positivity (apoptosis) was greater in DM lesions than DL ( P &lt; .05) and DI ( P &lt; .0001), and was linked to higher numbers of MAP within the macrophage.\n                  <\/jats:p>","DOI":"10.1177\/03009858211025790","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T05:28:37Z","timestamp":1625030917000},"page":"1086-1090","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Apoptosis levels in bovine Johne\u2019s disease ileal lesions and association with bacterial numbers"],"prefix":"10.1177","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5613-441X","authenticated-orcid":false,"given":"Amalia Naranjo-","family":"Lucena","sequence":"first","affiliation":[{"name":"University College Dublin, Dublin, 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Wolfe","sequence":"additional","affiliation":[{"name":"University College Dublin, Dublin, 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