{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T09:52:17Z","timestamp":1786787537494,"version":"build-2736575974"},"reference-count":43,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:00:00Z","timestamp":1626739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H03122"],"award-info":[{"award-number":["19H03122"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>To elucidate the histopathological characteristics and immunophenotypes of canine transmural \u201cmass-forming\u201d gastrointestinal lymphomas and plasmacytomas, 83 surgically resected biopsy samples were examined. All lymphomas and plasmacytomas were located in the small or large intestine except for 1 plasmacytoma which was in the stomach. According to the World Health Organization (WHO) classification, B-cell neoplasms (17 cases) included lymphoplasmacytic lymphoma (6\/17), plasmacytoma (5\/17), follicular lymphoma (3\/17), and diffuse large B-cell lymphoma (3\/17). Based on nuclear sizes, T-cell neoplasms (66 cases) were broadly divided into large cell lymphoma (LCL; 48\/66) and small cell lymphoma (SCL; 18\/66). According to the WHO classification, T-cell neoplasms included anaplastic large T-cell lymphoma (ALCL; 10\/66), angiotropic T-cell lymphoma (3\/66), mixed inflammatory type peripheral T-cell lymphoma (mixed inflammatory type PTCL; 33\/66), and PTCL-not otherwise specified (PTCL-NOS; 20\/66). Mixed inflammatory type PTCLs were further divided into histiocyte- (27\/33) and eosinophil- (6\/33) dominant types. Immunohistochemically, lymphoplasmacytic lymphomas were positive for Pax5 (6\/6) and IgM (5\/6), while plasmacytomas were positive for IgG (5\/6) and negative for Pax5. LCLs were immunopositive for granzyme B in 31\/48 cases (65%) and CD8 in 9\/48 cases (19%), while SCLs were immunopositive for granzyme B in 3\/18 cases (17%) and CD8 in 3\/18 cases (17%). Furthermore, 8\/10 cases (80%) of ALCL and 19\/27 cases (70%) of histiocyte-dominant PTCL were immunopositive for granzyme B, whereas 6\/20 cases (30%) of PTCL-NOS, 1\/6 cases (17%) of eosinophil-dominant PTCL, and no cases of angiotropic T-cell lymphomas were immunopositive for granzyme B. The present study describes the immunophenotypes in different histological types of transmural gastrointestinal lymphomas in the dog.<\/jats:p>","DOI":"10.1177\/03009858211030523","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T05:07:49Z","timestamp":1626757669000},"page":"1033-1043","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Histopathological features and immunophenotyping of canine transmural gastrointestinal lymphoma using full-thickness biopsy samples"],"prefix":"10.1177","volume":"58","author":[{"given":"Kazuhiro","family":"Kojima","sequence":"first","affiliation":[{"name":"The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5273-7221","authenticated-orcid":false,"given":"James K.","family":"Chambers","sequence":"additional","affiliation":[{"name":"The University of Tokyo, 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