{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:30:23Z","timestamp":1777919423386,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T00:00:00Z","timestamp":1641168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Massey University School of Veterinary Science Postgraduate Research Fund","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>Twelve cases of adult-onset blindness were identified in a flock of 130 polled Wiltshire sheep in New Zealand over a 3-year period. Affected sheep developed night blindness between 2 and 3 years of age, which progressed to complete blindness by 4 to 5 years of age. Fundic examination findings included progressive tapetal hyperreflectivity and attenuation of retinal blood vessels. Histologically, the retinas had a selective loss of rod photoreceptors with initial preservation of cone photoreceptors. Retinal degeneration was not accompanied by any other ocular or central nervous system abnormalities, and pedigree analysis suggested an inherited basis for the disease. Mating an affected Wiltshire ram to 2 affected Wiltshire ewes resulted in 6 progeny that all developed retinal degeneration by 2 years of age, while mating of the same affected ram to 6 unaffected ewes resulted in 8 unaffected progeny, consistent with autosomal recessive inheritance. Homozygosity mapping of 5 affected Wiltshire sheep and 1 unaffected Wiltshire sheep using an OvineSNP50 Genotyping BeadChip revealed an identical-by-descent region on chromosome 5, but none of the genes within this region were considered plausible candidate genes. Whole-genome sequencing of 2 affected sheep did not reveal any significant mutations in any of the genes associated with retinitis pigmentosa in humans or progressive retinal atrophy in dogs. Inherited progressive retinal degeneration affecting rod photoreceptors has not been previously reported in sheep, but this disease has several similarities to inherited retinal dystrophies in other species.<\/jats:p>","DOI":"10.1177\/03009858211067461","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T04:16:13Z","timestamp":1641183373000},"page":"310-318","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["An inherited night blindness in Wiltshire sheep"],"prefix":"10.1177","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7810-0560","authenticated-orcid":false,"given":"Hayley","family":"Hunt","sequence":"first","affiliation":[{"name":"Massey University, Palmerston North, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1813-2197","authenticated-orcid":false,"given":"Keren E.","family":"Dittmer","sequence":"additional","affiliation":[{"name":"Massey University, Palmerston North, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8640-5372","authenticated-orcid":false,"given":"Dorian J.","family":"Garrick","sequence":"additional","affiliation":[{"name":"Massey University, Palmerston North, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Fairley","sequence":"additional","affiliation":[{"name":"Gribbles Veterinary Pathology Ltd, Christchurch, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Heap","sequence":"additional","affiliation":[{"name":"McMaster and Heap Veterinary Practice, Christchurch, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D.","family":"Jolly","sequence":"additional","affiliation":[{"name":"Massey University, Palmerston North, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,1,3]]},"reference":[{"key":"bibr1-03009858211067461","doi-asserted-by":"publisher","DOI":"10.1071\/AR9660521"},{"issue":"13","key":"bibr2-03009858211067461","first-page":"4145","volume":"50","author":"Banin E","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr3-03009858211067461","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008689"},{"key":"bibr4-03009858211067461","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22004"},{"issue":"6","key":"bibr5-03009858211067461","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/ceo.13516","volume":"47","author":"Birtel J","year":"2019","journal-title":"Clin Exp Ophthalmol"},{"key":"bibr6-03009858211067461","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(00)00031-8"},{"key":"bibr7-03009858211067461","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-2353-3.10014-9"},{"key":"bibr8-03009858211067461","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.1982.34903"},{"key":"bibr9-03009858211067461","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-019-01999-6"},{"key":"bibr10-03009858211067461","doi-asserted-by":"publisher","DOI":"10.4161\/fly.19695"},{"key":"bibr11-03009858211067461","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2002.tb10847.x"},{"key":"bibr12-03009858211067461","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.10.004"},{"key":"bibr13-03009858211067461","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12122"},{"issue":"3","key":"bibr14-03009858211067461","first-page":"250","volume":"10","author":"Eveleth D","year":"1949","journal-title":"Am J Vet Res"},{"key":"bibr15-03009858211067461","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1999.tb11718.x"},{"issue":"3","key":"bibr16-03009858211067461","first-page":"294","volume":"25","author":"Graydon RJ","year":"1984","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bibr17-03009858211067461","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/13.5.543"},{"key":"bibr18-03009858211067461","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69740-7"},{"key":"bibr19-03009858211067461","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.55.979"},{"key":"bibr20-03009858211067461","unstructured":"Hunt H. 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