{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T15:31:22Z","timestamp":1784993482225,"version":"3.55.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>Pithomycotoxicosis (facial eczema) is a seasonal hepatogenous photosensitization of sheep caused by the ingestion of sporidesmin contained in the spores of the fungus Pithomyces chartarum. We describe 4 cases of obstructive rhinopathy associated with chronic pithomycotoxicosis naturally occurring in the north of Spain. Sheep were 5 to 7 years old and Latxa breed. A detailed clinical study was conducted together with computerized tomography examination and completed by necropsy and histopathology. All sheep developed a permanent narrowing of the nasal lumen close to the nostrils causing inspiratory dyspnea and snoring. Computerized tomography demonstrated a significant increase of soft tissue in the rostral nasal cavity. Elevated gamma-glutamyl transferase, alanine aminotransferase, and lipase were noted on serum biochemistry. At necropsy, liver atrophy and fibrosis associated with chronic pithomycotoxicosis was identified in 3 of the sheep. All sheep had whitish elevations and rough surfaces on the alar folds and areas adjacent to the nasal surfaces. Histopathologic assessments, which included histochemical and immunohistochemical techniques, of the nasal lesions identified moderate to severe arteriosclerosis in 21.5% to 61.9% of the small arteries evaluated with surrounding fibrosis and edema. No changes associated with hypersensitivity reactions were found. These lesions were similar to the ones described in blood vessels of the liver in chronic pithomycotoxicosis and in our cases. The results of this study suggest a direct action of the sporidesmin on the rostral nasal cavity. Further studies are needed to analyze the impact of the sporidesmin on the sheep nasal mucosa.<\/jats:p>","DOI":"10.1177\/03009858221109095","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T08:56:55Z","timestamp":1657011415000},"page":"950-959","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Chronic pithomycotoxicosis associated with obstructive rhinopathy in sheep"],"prefix":"10.1177","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3792-287X","authenticated-orcid":false,"given":"Marcelo","family":"De las Heras","sequence":"first","affiliation":[{"name":"Universidad de Zaragoza, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia","family":"Lacasta","sequence":"additional","affiliation":[{"name":"Universidad de Zaragoza, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal A.","family":"Res\u00e9ndiz","sequence":"additional","affiliation":[{"name":"Universidad de Zaragoza, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ane","family":"Rivas","sequence":"additional","affiliation":[{"name":"Veterinary Practitioner, Basque Country, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ane","family":"Garzianda","sequence":"additional","affiliation":[{"name":"Gomiztegi Koop, Basque Country, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"de Miguel","sequence":"additional","affiliation":[{"name":"AnaPath Research S.A.U, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Universidad de Zaragoza, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Castells","sequence":"additional","affiliation":[{"name":"Centro Cl\u00ednico Veterinario, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n y Tecnolog\u00eda Agroalimentaria de Arag\u00f3n, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis M.","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Universidad de Zaragoza, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,7,5]]},"reference":[{"key":"bibr1-03009858221109095","doi-asserted-by":"publisher","DOI":"10.1186\/BF03546843"},{"key":"bibr2-03009858221109095","unstructured":"Berriatua E, Garc\u00eda-SanMartin MJ, G\u00f3mez N, et al. Ovine chronic nasal stertor (OCNAS): epidemiological and clinic-pathological description and relationship with sporidesmosis (ovine facial eczema). Proceeding of the 10th international symposium on veterinary epidemiology and economics. Published 2003. Accessed June 14, 2022. http:\/\/www.sciquest.org.nz."},{"key":"bibr3-03009858221109095","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvc.2017.12.001"},{"key":"bibr4-03009858221109095","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13030179"},{"key":"bibr5-03009858221109095","doi-asserted-by":"publisher","DOI":"10.1177\/030098587901600106"},{"key":"bibr6-03009858221109095","doi-asserted-by":"publisher","DOI":"10.1177\/0300985813513042"},{"key":"bibr7-03009858221109095","doi-asserted-by":"publisher","DOI":"10.1080\/00288233.1961.10431612"},{"key":"bibr8-03009858221109095","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2018.00105"},{"key":"bibr9-03009858221109095","doi-asserted-by":"publisher","DOI":"10.1080\/00288230909510519"},{"key":"bibr10-03009858221109095","doi-asserted-by":"publisher","DOI":"10.1080\/00288233.1962.10419976"},{"key":"bibr11-03009858221109095","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(18)35033-1"},{"key":"bibr12-03009858221109095","doi-asserted-by":"publisher","DOI":"10.3390\/ani11041070"},{"key":"bibr13-03009858221109095","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.27847-0"},{"key":"bibr14-03009858221109095","volume-title":"Paper presented at the IV Jornadas sobre producci\u00f3n Animal ITEA","author":"Gonz\u00e1lez L"},{"key":"bibr15-03009858221109095","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2020.1729268"},{"key":"bibr16-03009858221109095","first-page":"383","volume":"27","author":"Le Bars J","year":"1996","journal-title":"Vet Res"},{"key":"bibr17-03009858221109095","volume-title":"Manual of Histological Staining Methods of the Armed Forces Institute of Pathology","author":"Luna LG","year":"1968","edition":"3"},{"key":"bibr18-03009858221109095","first-page":"107","volume":"39","author":"Marasas WFO","year":"1972","journal-title":"Onderstepoort J Vet Res"},{"key":"bibr19-03009858221109095","volume-title":"Staining Methods. Histological and Histochemical","author":"McManus JFA","year":"1960"},{"key":"bibr20-03009858221109095","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(18)34895-1"},{"key":"bibr21-03009858221109095","doi-asserted-by":"publisher","DOI":"10.1177\/1040638719855108"},{"key":"bibr22-03009858221109095","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2020.1823904"},{"key":"bibr23-03009858221109095","first-page":"40","volume":"256","author":"Natorp JC.","year":"2005","journal-title":"Point Veterinaire"},{"key":"bibr24-03009858221109095","volume-title":"Manual de anatom\u00eda patol\u00f3gica","author":"Ram\u00f3n Cajal S","year":"1900","edition":"3"},{"key":"bibr25-03009858221109095","doi-asserted-by":"publisher","DOI":"10.1177\/1040638713504572"},{"key":"bibr26-03009858221109095","first-page":"56","volume-title":"Pathology of Domestic Animals","author":"Robinson WF","year":"2016","edition":"6"},{"key":"bibr27-03009858221109095","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.02.008"},{"key":"bibr28-03009858221109095","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2000.36189"},{"key":"bibr29-03009858221109095","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.1991.35650"},{"key":"bibr30-03009858221109095","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.1980.34686"},{"key":"bibr31-03009858221109095","volume-title":"Pathologic Basis of Veterinary Disease","author":"Snyder PW","edition":"7"},{"key":"bibr32-03009858221109095","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1987.tb00427.x"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03009858221109095","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03009858221109095","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03009858221109095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:03:26Z","timestamp":1777662206000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03009858221109095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,5]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1177\/03009858221109095"],"URL":"https:\/\/doi.org\/10.1177\/03009858221109095","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,5]]}}}