{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:06:30Z","timestamp":1787018790337,"version":"build-2736575974"},"reference-count":33,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>Cutaneous mast cell tumor (MCT) is one of the most frequent cutaneous neoplasms of dogs and may vary from well-differentiated to aggressive tumors with metastasis. The authors retrospectively described the gross and histologic aspects of metastatic MCT in 49 dogs. Primary MCT was most commonly identified in the inguinal region (14\/35; 40%), and at necropsy multiple, cutaneous nodules were frequently reported (23\/49; 47%). All primary MCT were classified as high-grade neoplasms, and metastases involved the lymph nodes (47\/49; 96%), spleen (33\/49; 67%), liver (29\/49; 59%), bone marrow (20\/49; 41%), kidneys (16\/49; 33%), and heart (14\/49; 29%), while the lungs were less commonly affected (9\/49; 18%). The main gross findings included lymphadenomegaly in 47 cases; splenomegaly in 28 cases, with splenic nodules in 13 dogs; hepatomegaly in 28 cases, with white pinpoint foci in 9 cases; nodules on the capsular surface of the kidneys in 9 dogs; and epicardial nodules in 6 cases. Histologically, the lymph nodes were largely obliterated by neoplastic mast cells, while in the spleen, neoplastic cells were multifocally scattered (16\/33; 48%), arranged in nodules (10\/33; 30%), or obliterated the parenchyma (9\/33; 27%). In the liver, the neoplastic cells mainly infiltrated the sinusoids (24\/29; 83%), but were also arranged in random nodules (10\/29; 34%). Interstitial and nodular metastases were observed in the kidneys and the heart. Grossly unapparent metastases were common in the heart (6\/14; 43%), kidneys (4\/16; 25%), and lungs (6\/9). KIT III and KIT II staining patterns were observed in 29 and 20 cases, respectively.<\/jats:p>","DOI":"10.1177\/03009858221114468","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T07:20:45Z","timestamp":1658733645000},"page":"922-930","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Pathological aspects of cutaneous mast cell tumors with metastases in 49 dogs"],"prefix":"10.1177","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3530-3151","authenticated-orcid":false,"given":"Paula Reis","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3951-0038","authenticated-orcid":false,"given":"Matheus Viezzer","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcele Bettim","family":"Bandinelli","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9461-7428","authenticated-orcid":false,"given":"Rafael Biondo","family":"Rosa","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna Vargas Zillig","family":"Echenique","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alanna","family":"Serpa Stolf","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Driemeier","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Sonne","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saulo Petinatti","family":"Pavarini","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12581"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2012.00341.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2011.01839.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2006.00115.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300985817747325"},{"key":"e_1_3_2_7_2","first-page":"102","article-title":"Pathologic report of 29 necropsies on dogs with mastocytoma","volume":"5","author":"Hottendorf GH","year":"1968","unstructured":"Hottendorf GH, Nielsen SW. 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