{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:06:29Z","timestamp":1787018789527,"version":"build-2736575974"},"reference-count":31,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:p>Invertebrates, including arachnids, are a common taxon in zoological collections. Invertebrate medicine and pathology are emerging subspecialties, but there is limited reference material or published resources describing histologic lesions in arachnids. Histopathology of 26 captive arachnids (20 spiders and 6 scorpions) from institutional collections was reviewed. Most animals were found dead with limited clinical signs. Tissues evaluated included body wall (cuticle and epidermis), skeletal muscle, book lungs, digestive tract (pharynx, esophagus, sucking stomach, midgut tube, midgut diverticula, and stercoral pocket), central and peripheral nervous system, heart, hemolymph vessels and sinuses, Malpighian tubules, coxal glands, and gonads. Inflammation was frequent (24\/26, 92%), and seen in multiple organs (18\/24, 75%) with the midgut diverticulum most commonly affected (14\/24, 58%) followed by the book lungs (13\/24 arachnids, 54%), and body wall (8\/24 arachnids, 33%). Inflammation comprised hemocyte accumulation, hemocytic coagula, melanization, and nodulation. Infectious agents, including bacteria (11\/26, 42%), fungi (10\/26, 38%), and parasites (2\/26, 8%), were seen within inflammatory aggregates. Coinfection with multiple infectious agents was common (6\/24, 25%). No etiologic agent was identified in 7\/24 (29%) cases with inflammatory lesions. Lesions suggestive of decreased nutritional status or increased metabolic rate included midgut diverticula atrophy in 11\/26 (42%) animals and skeletal muscle atrophy in 6\/26 (23%) animals. Atrophic lesions were seen in combination with infection (8\/11, 73%), pregnancy (2\/11, 18%), male sex (2\/11, 18%), or without other lesions (1\/11, 9%). Other suspected contributors to death included dysecdysis-associated trauma (2\/26, 8%) and uterine intussusception (1\/26, 4%). No animals had neoplasia.<\/jats:p>","DOI":"10.1177\/03009858231162948","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T06:45:01Z","timestamp":1681109101000},"page":"652-666","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Retrospective analysis of histologic lesions in captive arachnids"],"prefix":"10.1177","volume":"60","author":[{"given":"Chris","family":"Gaudette","sequence":"first","affiliation":[{"name":"North Carolina State University, Raleigh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8510-1051","authenticated-orcid":false,"given":"Elise E. 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