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In some regions of the world, oomycetes, such as Pythium and Lagenidium, are also responsible for a significant number of severe cutaneous infections. Histologic evaluation of fungal morphology, including size, shape, septation, branching, and budding characteristics, combined with the distribution of inflammatory infiltrates within different skin layers can potentially identify etiologic agents, guiding selection of antifungals and additional diagnostics. Fungal infections of the skin surface are typically caused by Malassezia and rarely Candida, with opportunistic fungi also capable of colonizing the skin surface, especially when the barrier is broken. Folliculocentric infections, caused by dermatophytes, result in mild to severe inflammation and can occasionally penetrate deep into the skin. A wide range of fungi, including agents of hyalohyphomycosis, phaeohyphomycosis, and dimorphic fungal infections, as well as oomycetes, result in nodular cutaneous and subcutaneous lesions. With the occasional exception of dimorphic fungi, fungal speciation often requires cultures performed on fresh tissues. However, molecular techniques such as pan-fungal polymerase chain reaction on paraffin blocks is becoming an increasingly useful tool to distinguish between cutaneous fungal pathogens. This review focuses on describing the clinical and histologic features of the most common fungal and oomycete infections affecting the skin of animals, divided according to distribution patterns of lesions and fungal or oomycete morphology.<\/jats:p>","DOI":"10.1177\/03009858231173715","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T05:17:46Z","timestamp":1684905466000},"page":"812-828","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Hyphae, pseudohyphae, yeasts, spherules, spores, and more: A review on the morphology and pathology of fungal and oomycete infections in the skin of domestic animals"],"prefix":"10.1177","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6148-2531","authenticated-orcid":false,"given":"Aline","family":"Rodrigues Hoffmann","sequence":"first","affiliation":[{"name":"University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maiara G.","family":"Ramos","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall T.","family":"Walker","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0746-5949","authenticated-orcid":false,"given":"Lauren W.","family":"Stranahan","sequence":"additional","affiliation":[{"name":"Texas A&M University, College Station, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,5,24]]},"reference":[{"key":"bibr1-03009858231173715","first-page":"711","volume":"191","author":"Abid HN","year":"1987","journal-title":"J Am Vet Med Assoc"},{"key":"bibr2-03009858231173715","doi-asserted-by":"publisher","DOI":"10.1053\/jfms.2002.0183"},{"key":"bibr3-03009858231173715","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2022.01.007"},{"key":"bibr4-03009858231173715","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0250695"},{"key":"bibr5-03009858231173715","doi-asserted-by":"publisher","DOI":"10.1177\/03009858221075589"},{"key":"bibr6-03009858231173715","doi-asserted-by":"publisher","DOI":"10.1038\/nrg948"},{"key":"bibr7-03009858231173715","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myu082"},{"key":"bibr8-03009858231173715","first-page":"75","volume":"31","author":"Bond R","year":"2020","journal-title":"Vet Dermatol"},{"key":"bibr9-03009858231173715","volume":"4","author":"Brooks IJ","year":"2018","journal-title":"JFMS Open Rep"},{"key":"bibr10-03009858231173715","volume-title":"Histopathologic Preparations: Common Problems and their Solutions","author":"Brown RW.","year":"2009","edition":"1"},{"key":"bibr11-03009858231173715","doi-asserted-by":"publisher","DOI":"10.1177\/1040638720958338"},{"key":"bibr12-03009858231173715","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myu062"},{"key":"bibr13-03009858231173715","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.2002.00762.x"},{"key":"bibr14-03009858231173715","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02112-15"},{"key":"bibr15-03009858231173715","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-6768"},{"key":"bibr16-03009858231173715","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2022.07.012"},{"key":"bibr17-03009858231173715","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-020-02597-9"},{"key":"bibr18-03009858231173715","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2013.06.007"},{"key":"bibr19-03009858231173715","doi-asserted-by":"publisher","DOI":"10.1177\/1040638720968937"},{"key":"bibr20-03009858231173715","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2008.07.005"},{"key":"bibr21-03009858231173715","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-280X.1999.00248.x"},{"key":"bibr22-03009858231173715","doi-asserted-by":"publisher","DOI":"10.1046\/j.0959-4493.2001.00262.x"},{"key":"bibr23-03009858231173715","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-018-1589-7"},{"key":"bibr24-03009858231173715","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1997.tb03439.x"},{"key":"bibr25-03009858231173715","doi-asserted-by":"publisher","DOI":"10.1111\/jam.15084"},{"key":"bibr26-03009858231173715","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-021-00529-1"},{"key":"bibr27-03009858231173715","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1998.tb03739.x"},{"key":"bibr28-03009858231173715","doi-asserted-by":"publisher","DOI":"10.5326\/0440226"},{"key":"bibr29-03009858231173715","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2002.221.528"},{"key":"bibr30-03009858231173715","unstructured":"Grooters AM. 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