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Spinal lesions were categorized according to pathologic process: degenerative (78\/86, 91%), developmental (8\/86, 9%), inflammatory (6\/86, 7%), or neoplastic (8\/86, 9%). Degenerative lesions included intervertebral disk disease (IVDD; 66\/78, 85%), spondylosis without concurrent IVDD (4\/78, 5%), and idiopathic (noncompressive) degenerative myelopathies (8\/78, 10%). Fourteen individuals had lesions in more than 1 category. Developmental cases were vertebral (4\/8) or spinal cord (3\/8) malformations or both (1\/8). Inflammatory lesions included meningitis (4\/6) and meningomyelitis (2\/6). Neoplasia included vertebral multiple myeloma (4\/8) and others (4\/8). IVDD often involved multiple disks but primarily affected the cervical (41\/66, 62%) and thoracic spine (32\/66, 48%). A multivariate binary logistic model predicted the diagnosis of IVDD at postmortem examination, where odds of being affected were highest for males, lions ( Panthera leo), and geriatric age group (&gt;14 years). The spinal lesions documented in this study provide insight into high-risk signalment categories and predominant associated lesions affecting captive Panthera populations. Specifically, spinal disease, especially cervical IVDD, is common among Panthera species, and lions, males, and older felids are at increased risk.<\/jats:p>","DOI":"10.1177\/03009858231203313","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T08:05:26Z","timestamp":1697011526000},"page":"248-255","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Spinal disease in a captive population of\n                    <i>Panthera<\/i>\n                    species: Review of 86 cases (2003\u20132021)"],"prefix":"10.1177","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7832-7829","authenticated-orcid":false,"given":"Abbie","family":"Metcalfe","sequence":"first","affiliation":[{"name":"The University of Tennessee, Knoxville, 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