{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:31:47Z","timestamp":1777919507587,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:p>Pedigree analysis, clinical, gross, microscopic, ultrastructural, and lipidomic findings in 4 female superb bird-of-paradise (SBOP, Lophorina superba) siblings led to the diagnosis of a primary inherited glycerolipid storage disease. These birds were the offspring of a related breeding pair (inbreeding coefficient = 0.1797) and are the only known SBOPs to display this constellation of lesions. The birds ranged from 0.75 to 4.3 years of age at the time of death. Two birds were euthanized and 1 died naturally due to the disease, and 1 died of head trauma with no prior clinical signs. Macroscopic findings included hepatomegaly and pallor (4\/4), cardiac and renal pallor (2\/4), and coelomic effusion (1\/4). Microscopic examination found marked tissue distortion due to cytoplasmic lipid vacuoles in hepatocytes (4\/4), cardiomyocytes (4\/4), renal tubular epithelial cells (4\/4), parathyroid gland principal cells (2\/2), exocrine pancreatic cells (3\/3), and the glandular cells of the ventriculus and proventriculus (3\/3). Ultrastructurally, the lipids were deposited in single to coalescing or fused droplets lined by an inconspicuous or discontinuous monolayer membrane. Lipidomic profiling found that the cytoplasmic lipid deposits were primarily composed of triacylglycerols. Future work, including sequencing of the SBOP genome and genotyping, will be required to definitively determine the underlying genetic mechanism of this disease.<\/jats:p>","DOI":"10.1177\/03009858231203314","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T07:02:43Z","timestamp":1697439763000},"page":"288-297","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lipid storage disease in 4 sibling superb birds-of-paradise (\n                    <i>Lophorina superba<\/i>\n                    )"],"prefix":"10.1177","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7418-2941","authenticated-orcid":false,"given":"Christina M.","family":"McKenzie","sequence":"first","affiliation":[{"name":"San Diego Zoo Wildlife Alliance, San Diego, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matt","family":"Marinkovich","sequence":"additional","affiliation":[{"name":"San Diego Zoo Wildlife Alliance, San Diego, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1870-9945","authenticated-orcid":false,"given":"An\u00edbal G.","family":"Armi\u00e9n","sequence":"additional","affiliation":[{"name":"University of California, Davis, Davis, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy St.","family":"Leger","sequence":"additional","affiliation":[{"name":"Cornell University, Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron M.","family":"Armando","sequence":"additional","affiliation":[{"name":"University of California, San Diego, La Jolla, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3738-3140","authenticated-orcid":false,"given":"Edward A.","family":"Dennis","sequence":"additional","affiliation":[{"name":"University of California, San Diego, La Jolla, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oswald","family":"Quehenberger","sequence":"additional","affiliation":[{"name":"University of California, San Diego, La Jolla, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Righton","sequence":"additional","affiliation":[{"name":"San Diego Zoo Wildlife Alliance, San Diego, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"key":"bibr1-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1177\/0300985819891240"},{"key":"bibr2-03009858231203314","unstructured":"Ballou JD, Lacy RC, Pollak JP. PMx: Software for demographic and genetic analysis and management of pedigreed populations (Version 1.6.5.20220325). Brookfield, IL: Chicago Zoological Society; 2022. http:\/\/www.scti.tools."},{"key":"bibr3-03009858231203314","doi-asserted-by":"publisher","DOI":"10.2460\/javma.242.12.1696"},{"key":"bibr4-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12895"},{"key":"bibr5-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0240449"},{"key":"bibr6-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1177\/0300985818800025"},{"key":"bibr7-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1637\/9853-071911-Reg.1"},{"key":"bibr8-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2003.11.001"},{"key":"bibr9-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1007\/s11897-013-0133-0"},{"key":"bibr10-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1647\/2010-045.1"},{"key":"bibr11-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1080\/03079457.2017.1380293"},{"key":"bibr12-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1126\/science.1123965"},{"key":"bibr13-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.98"},{"key":"bibr14-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.0c03016"},{"key":"bibr15-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4470"},{"key":"bibr16-03009858231203314","doi-asserted-by":"publisher","DOI":"10.7589\/JWD-D-20-00173"},{"issue":"1","key":"bibr17-03009858231203314","first-page":"69","volume":"70","author":"Jones M","year":"1973","journal-title":"Am J Pathol"},{"key":"bibr18-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1638\/2011-0157.1"},{"key":"bibr19-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(97)00092-6"},{"key":"bibr20-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-010-0154-y"},{"key":"bibr21-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E19-05-0284"},{"key":"bibr22-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1038\/srep27688"},{"key":"bibr23-03009858231203314","unstructured":"Lophorinasuperba. CITES. https:\/\/cites.org\/eng\/taxonomy\/term\/2730."},{"key":"bibr24-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-021-03934-3"},{"key":"bibr25-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1186\/s40169-018-0182-9"},{"key":"bibr26-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2021.100127"},{"key":"bibr27-03009858231203314","doi-asserted-by":"publisher","DOI":"10.3390\/cells8020187"},{"key":"bibr28-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.05.011"},{"key":"bibr29-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-009-9941-4"},{"key":"bibr30-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0085-z"},{"key":"bibr31-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-017-0646-9"},{"key":"bibr32-03009858231203314","unstructured":"Proudfoot JS, Garner MM, Prieur D, Brown R. Lysosomal Storage Disease in Costa\u2019s Hummingbirds (Calypte costae). IAAAM. 2000. https:\/\/www.vin.com\/apputil\/content\/defaultadv1.aspx?pId=26436&id=9992709."},{"key":"bibr33-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M009449"},{"key":"bibr34-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1136\/vr.122.8.187"},{"key":"bibr35-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1002\/zoo.21627"},{"key":"bibr36-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a004804"},{"key":"bibr37-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00099.2009"},{"key":"bibr38-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1090.1970.tb01299.x"},{"key":"bibr39-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1354\/vp.43-6-1029"},{"key":"bibr40-03009858231203314","volume-title":"Pathologic basis of veterinary disease","author":"Zachary JF","year":"2017"},{"key":"bibr41-03009858231203314","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2008.06.010"},{"key":"bibr42-03009858231203314","unstructured":"ZIMS for Studbooks for Association of Zoos Aquariums\/Lophorina superba (Theule, J., 4\/18\/2023). Species360 Zoological Information Management System. http:\/\/zims.Species360.org."}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03009858231203314","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03009858231203314","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03009858231203314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:04:45Z","timestamp":1777662285000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03009858231203314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,16]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1177\/03009858231203314"],"URL":"https:\/\/doi.org\/10.1177\/03009858231203314","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,16]]}}}