{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:23:34Z","timestamp":1788344614770,"version":"build-2803163510"},"reference-count":42,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National Institute of Allergy and Infectious Diseases","award":["K08AI141767"],"award-info":[{"award-number":["K08AI141767"]}]},{"name":"National Institute of Allergy and Infectious Diseases","award":["K08AI163401"],"award-info":[{"award-number":["K08AI163401"]}]},{"name":"NIH Office of the Director","award":["T32ODO011000"],"award-info":[{"award-number":["T32ODO011000"]}]},{"name":"National Institute of Food and Agriculture","award":["2020-67015-31297"],"award-info":[{"award-number":["2020-67015-31297"]}]},{"name":"National Institute of Food and Agriculture","award":["2022-67015-36343"],"award-info":[{"award-number":["2022-67015-36343"]}]},{"name":"Harry M. Zweig Memorial Fund for Equine Research"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>Equine parvovirus-hepatitis (EqPV-H) is the causative agent of Theiler\u2019s disease, or severe acute hepatic necrosis, in horses. However, it is poorly understood whether EqPV-H is associated with other histologic findings in horses with clinical liver disease. The objective of this study was to examine the prevalence and severity of EqPV-H infections in diagnostic liver samples. Archived formalin-fixed, paraffin-embedded (FFPE) liver samples ( n = 98) from Cornell University and University of California, Davis, collected between 2007 and 2022 were evaluated for 15 individual histologic features and by EqPV-H in situ hybridization. EqPV-H was detected in 48% ( n = 47) of samples. The most common histologic features of EqPV-H-positive samples included individual hepatocyte death ( n = 40, 85%), lobular infiltrates ( n = 38, 80%), portal infiltrates ( n = 35, 74%), and ductular reaction ( n = 33, 70%). Centrilobular necrosis, portal infiltrate, and individual hepatocyte death were positively associated with high viral load. Neutrophil infiltrates, bridging fibrosis, and portal edema were negatively associated with a high viral load. Only 4 of 49 tested samples were positive for equine hepacivirus by polymerase chain reaction (PCR), but the PCR assay was unreliable for FFPE tissues. In summary, this study demonstrates that EqPV-H is common in a variety of liver pathologies and should be considered as a differential diagnosis in cases of hepatitis other than Theiler\u2019s disease.<\/jats:p>","DOI":"10.1177\/03009858231214024","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T03:32:45Z","timestamp":1701228765000},"page":"442-452","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Naturally acquired equine parvovirus-hepatitis is associated with a wide range of hepatic lesions in horses"],"prefix":"10.1177","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6036-9895","authenticated-orcid":false,"given":"Mason C.","family":"Jager","sequence":"first","affiliation":[{"name":"Cornell University, Ithaca, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunju","family":"Choi","sequence":"additional","affiliation":[{"name":"University of California, Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7365-3967","authenticated-orcid":false,"given":"Joy E.","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"Cornell University, Ithaca, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerlinde","family":"Van de Walle","sequence":"additional","affiliation":[{"name":"Cornell University, Ithaca, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"key":"bibr1-03009858231214024","doi-asserted-by":"publisher","DOI":"10.3390\/v11100942"},{"key":"bibr2-03009858231214024","doi-asserted-by":"publisher","DOI":"10.1111\/evj.13444"},{"key":"bibr3-03009858231214024","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2019.108575"},{"key":"bibr4-03009858231214024","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00250-12"},{"key":"bibr5-03009858231214024","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-5318-4.00008-5"},{"key":"bibr6-03009858231214024","doi-asserted-by":"publisher","DOI":"10.3201\/eid2402.171031"},{"key":"bibr7-03009858231214024","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12551"},{"key":"bibr8-03009858231214024","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-022-01901-3"},{"key":"bibr9-03009858231214024","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1101794108"},{"key":"bibr10-03009858231214024","doi-asserted-by":"publisher","DOI":"10.1111\/eve.12999"},{"key":"bibr11-03009858231214024","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci8110282"},{"key":"bibr12-03009858231214024","doi-asserted-by":"publisher","DOI":"10.1038\/s41426-018-0174-2"},{"key":"bibr13-03009858231214024","first-page":"7","author":"Lu G","year":"2020","journal-title":"Front Vet Sci"},{"key":"bibr14-03009858231214024","author":"Mann S","year":"2021","journal-title":"Equine Vet J"},{"key":"bibr15-03009858231214024","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2022.109557"},{"key":"bibr16-03009858231214024","doi-asserted-by":"publisher","DOI":"10.3390\/v11100965"},{"key":"bibr17-03009858231214024","doi-asserted-by":"publisher","DOI":"10.3390\/v11050461"},{"key":"bibr18-03009858231214024","author":"Moraes MV","year":"2021","journal-title":"Transbound Emerg Dis"},{"key":"bibr19-03009858231214024","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27440"},{"key":"bibr20-03009858231214024","doi-asserted-by":"publisher","DOI":"10.3390\/v10070384"},{"key":"bibr21-03009858231214024","doi-asserted-by":"publisher","DOI":"10.1177\/030098589303000405"},{"key":"bibr22-03009858231214024","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12652"},{"key":"bibr23-03009858231214024","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27689"},{"key":"bibr24-03009858231214024","doi-asserted-by":"publisher","DOI":"10.3390\/v13081454"},{"key":"bibr25-03009858231214024","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1500265112"},{"key":"bibr26-03009858231214024","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2016.02.007"},{"key":"bibr27-03009858231214024","doi-asserted-by":"publisher","DOI":"10.1177\/104063879600800113"},{"key":"bibr28-03009858231214024","doi-asserted-by":"publisher","DOI":"10.1136\/vr.j8"},{"key":"bibr29-03009858231214024","doi-asserted-by":"publisher","DOI":"10.1354\/vp.43-5-755"},{"key":"bibr30-03009858231214024","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.181"},{"key":"bibr31-03009858231214024","unstructured":"Theiler A. 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