{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:32:10Z","timestamp":1777919530883,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100016958","name":"Office of Research Infrastructure Programs","doi-asserted-by":"publisher","award":["K01 OD123219-03"],"award-info":[{"award-number":["K01 OD123219-03"]}],"id":[{"id":"10.13039\/100016958","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>Cutaneous plaques and squamous cell carcinoma (SCC) are common in captive North American snow leopards (SLs) ( Panthera uncia). Our objective was to determine whether these lesions are potentially associated with papillomavirus(es). Polymerase chain reaction (PCR) was performed on 3 cutaneous plaques using degenerate primers for papillomaviruses. A putatively novel papillomavirus was identified that shared 76% sequence identity to Felis catus papillomavirus 2. Specific PCR for this virus was performed on 5 cutaneous SCC samples and 7 normal skin samples, which were all positive. In situ hybridization for this putatively novel virus was performed, which revealed strong hybridization signals within hyperplastic cells in cutaneous plaques (n = 3) and within neoplastic cells in cutaneous SCC samples (n = 5). No hybridization signals were identified within normal skin. Ultimately, identification of a causal viral agent in the development of plaques and SCC in SLs will help guide therapeutic intervention and lay the foundation for development of prophylactic vaccines.<\/jats:p>","DOI":"10.1177\/03009858241254340","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T07:23:56Z","timestamp":1716276236000},"page":"973-977","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A putatively novel papillomavirus associated with cutaneous plaques and squamous cell carcinoma in captive North American snow leopards (\n                    <i>Panthera uncia<\/i>\n                    )"],"prefix":"10.1177","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0572-5791","authenticated-orcid":false,"given":"Mandy","family":"Womble","sequence":"first","affiliation":[{"name":"North Carolina State University College of Veterinary Medicine, Raleigh, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaina","family":"Weingart","sequence":"additional","affiliation":[{"name":"North Carolina State University College of Veterinary Medicine, Raleigh, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"May","sequence":"additional","affiliation":[{"name":"North Carolina State University College of Veterinary Medicine, Raleigh, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Garner","sequence":"additional","affiliation":[{"name":"Northwest ZooPath, Monroe, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0696-0243","authenticated-orcid":false,"given":"Jennifer","family":"Luff","sequence":"additional","affiliation":[{"name":"North Carolina State University College of Veterinary Medicine, Raleigh, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,5,21]]},"reference":[{"key":"bibr1-03009858241254340","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2020.00645"},{"key":"bibr2-03009858241254340","unstructured":"Joslin J, Garner M, Collins D, et al. Viral papilloma and squamous cell carcinomasin snow leopards (Uncia uncia). Veterinary Information Network. 2000. Accessed March 25, 2024. https:\/\/www.vin.com\/doc\/?id=3864513."},{"key":"bibr3-03009858241254340","unstructured":"Joslin J, Jenson AB, Ghim SJ, et al. Snow leopard (Uncia uncia) papillomavirus infection, vaccine development, serological testing, vaccination, and treatment options. Veterinary Information Network. 2012. Accessed March 25, 2024. https:\/\/www.vin.com\/doc\/?id=9846877."},{"key":"bibr4-03009858241254340","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2013.06.026"},{"key":"bibr5-03009858241254340","doi-asserted-by":"publisher","DOI":"10.1177\/1040638712443360"},{"key":"bibr6-03009858241254340","first-page":"749","volume-title":"Molecular Diagnostics of Human Cancer","volume":"1989","author":"Manos MM"},{"key":"bibr7-03009858241254340","doi-asserted-by":"publisher","DOI":"10.2305\/IUCN.UK.2017-2.RLTS.T22732A50664030.en"},{"key":"bibr8-03009858241254340","doi-asserted-by":"publisher","DOI":"10.1186\/1746-6148-7-38"},{"key":"bibr9-03009858241254340","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2013.11.025"},{"key":"bibr10-03009858241254340","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2011.00958.x"},{"key":"bibr11-03009858241254340","doi-asserted-by":"publisher","DOI":"10.1177\/0300985809358604"},{"key":"bibr12-03009858241254340","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2008.00685.x"},{"key":"bibr13-03009858241254340","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2017.04.018"},{"key":"bibr14-03009858241254340","doi-asserted-by":"publisher","DOI":"10.1354\/vp.37-1-1"},{"key":"bibr15-03009858241254340","doi-asserted-by":"crossref","unstructured":"Terio KA, McAloose D, Felidae Mitchelln\u00e9e Lane E. In: McAloose D, Terio K, Leger JSt., eds. Pathology of Wildlife and Zoo Animals. 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