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The aims were to describe kidney laboratory and microscopic findings in shelter cats with AA-amyloidosis. Cats were included if kidney specimens were collected post-mortem and laboratory data were available within 6 months before death. Renal lesions were evaluated with optical and electron microscopy. Mass spectrometry was used to characterize amyloid. Nine domestic short-hair cats were included; 4 females and 5 males with a median age of 8 years (range = 2\u201313). All cats had blood analyses and urinalyses available. Serum creatinine concentrations were increased in 6 cats and symmetric dimethylarginine was increased in all of the cats. All of the cats had proteinuria. Eight of 9 cats had amyloid in the medulla, and 9 had amyloid in the cortex (glomeruli). All cats had amyloid in the interstitium. Six cats had concurrent interstitial nephritis and 1 had membranoproliferative glomerulonephritis. All cats had extrarenal amyloid deposits. Amyloid was AA in each case. In conclusion, renal deposition of amyloid occurs in both cortex and medulla in shelter cats and is associated with azotemia and proteinuria. Renal involvement of systemic AA-amyloidosis should be considered in shelter cats with chronic kidney disease. The cat represents a natural model of renal AA-amyloidosis.<\/jats:p>","DOI":"10.1177\/03009858241257903","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T05:31:00Z","timestamp":1718170260000},"page":"771-782","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Renal alterations in cats (\n                    <i>Felis catus<\/i>\n                    ) housed in shelters and affected by systemic AA-amyloidosis: Clinicopathological data, histopathology, and ultrastructural features"],"prefix":"10.1177","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6727-2399","authenticated-orcid":false,"given":"Filippo","family":"Ferri","sequence":"first","affiliation":[{"name":"AniCura Istituto Veterinario Novara, Novara, Italy"},{"name":"Studio Veterinario Associato Vet2Vet di Ferri e Porporato, Torino, Italy"},{"name":"Department of Animal Medicine, Production and Health, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Ferro","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedicine and Food Sciences, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Lucia","family":"Benali","sequence":"additional","affiliation":[{"name":"Laboratorio MYLAV\u2014La Vallonea, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7893-1740","authenticated-orcid":false,"given":"Luca","family":"Aresu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Torino, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Muscardin","sequence":"additional","affiliation":[{"name":"AniCura Istituto Veterinario Novara, Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Porporato","sequence":"additional","affiliation":[{"name":"AniCura Istituto Veterinario Novara, Novara, Italy"},{"name":"Studio Veterinario Associato Vet2Vet di Ferri e Porporato, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Rossi","sequence":"additional","affiliation":[{"name":"AniCura Istituto Veterinario Novara, Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Guglielmetti","sequence":"additional","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale del Piemonte Liguria e Valle d\u2019Aosta, S.C. 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