{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:43:01Z","timestamp":1787679781050,"version":"build-2784847793"},"reference-count":40,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Tumors in boars are uncommon, and testicular tumors even rarer. This study describes the pathological and immunohistochemical characteristics of a case series of testicular tumors in commercial boars with fertility problems. Tumors were detected in 19 of 333 animals (19\/333, 5.9%). Macroscopically, tumors were observed in 13 (13\/19, 68%) boars, while 6 cases (6\/19, 32%) were only detected by microscopic examination. Testicular enlargement was observed in 1 boar, while in the others, tumors were only observed after removal of the scrotal skin or after sectioning of the testis. Histologically, tumors were classified as seminomas (16\/19, 84%), mixed germ cell-stromal tumors (2\/19, 11%), and B-cell lymphoma (1\/19, 5%). Seminomas had 3 different growth patterns: intratubular (6\/16, 38%), diffuse (4\/16, 25%), and intratubular\/diffuse (6\/16, 38%). All tumors that were not evident on macroscopic examination were intratubular seminomas. Intratesticular metastases were observed in 2 cases and extratesticular metastases, located in the pampiniform plexus, were observed in 1 case. In 1 seminoma, the rete testis was also involved. By immunohistochemistry, all intratubular seminomas were negative for c-kit, cytokeratin, and vimentin. In diffuse seminomas, c-kit and cytokeratin were also negative, while vimentin showed granular or perinuclear cytoplasmic labeling in some areas. PAX-5 and CD-3 antibodies classified the lymphoma as a B-cell lymphoma. This study suggests that testicular tumors in boars may be more common than previously reported, especially when microscopic examination is performed. It also shows that testicular tumors in pigs are predominantly seminomas.<\/jats:p>","DOI":"10.1177\/03009858241269836","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T03:04:08Z","timestamp":1723777448000},"page":"20-30","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Testicular tumors in commercial boars with infertility: A gross, histologic, and immunohistochemical study"],"prefix":"10.1177","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0770-9250","authenticated-orcid":false,"given":"Raquel","family":"Ausejo","sequence":"first","affiliation":[{"name":"Department of Veterinary R&D, Magapor S.L., Ejea de los Caballeros, Spain"},{"name":"Reproduction Unit, Pathology Department, Faculty of Veterinary Sciences, University of Zaragoza, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Victoria","family":"Falceto","sequence":"additional","affiliation":[{"name":"Reproduction Unit, Pathology Department, Faculty of Veterinary Sciences, University of Zaragoza, Zaragoza, Spain"},{"name":"Agrifood Institute of Arag\u00f3n (IA2), Pathology Department, Faculty of Veterinary Sciences, University of Zaragoza, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Mitjana","sequence":"additional","affiliation":[{"name":"Reproduction Unit, Pathology Department, Faculty of Veterinary Sciences, University of Zaragoza, Zaragoza, Spain"},{"name":"Agrifood Institute of Arag\u00f3n (IA2), Pathology Department, Faculty of Veterinary Sciences, University of Zaragoza, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Mar\u00eda","family":"Garrido","sequence":"additional","affiliation":[{"name":"Reproduction Unit, Pathology Department, Faculty of Veterinary Sciences, University of Zaragoza, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9","family":"Badiola","sequence":"additional","affiliation":[{"name":"Agrifood Institute of Arag\u00f3n (IA2), Pathology Department, Faculty of Veterinary Sciences, University of Zaragoza, Zaragoza, Spain"},{"name":"Research Center for TSE and Emerging Transmissible Diseases, Pathology Department, Faculty of Veterinary Sciences, University of Zaragoza, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6629-6842","authenticated-orcid":false,"given":"Bernardino","family":"Moreno","sequence":"additional","affiliation":[{"name":"Agrifood Institute of Arag\u00f3n (IA2), Pathology Department, Faculty of Veterinary Sciences, University of Zaragoza, Zaragoza, Spain"},{"name":"Research Center for TSE and Emerging Transmissible Diseases, Pathology Department, Faculty of Veterinary Sciences, University of Zaragoza, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"bibr1-03009858241269836","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci10070471"},{"key":"bibr2-03009858241269836","first-page":"689","volume-title":"Tumors of Domestic Animals","volume":"2016","author":"Agnew DW","edition":"5"},{"key":"bibr3-03009858241269836","doi-asserted-by":"publisher","DOI":"10.54846\/jshap\/439"},{"key":"bibr4-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2014.12.008"},{"key":"bibr5-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1309\/5FU2-8YQ9-Q12R-Y0KU"},{"key":"bibr6-03009858241269836","first-page":"33","volume":"116","author":"D\u00fcnzel G","year":"2009","journal-title":"DTW"},{"key":"bibr7-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2005.11.003"},{"key":"bibr8-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqy168"},{"key":"bibr9-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(78)90004-X"},{"key":"bibr10-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0531.2011.01784.x"},{"key":"bibr11-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2009.07.002"},{"key":"bibr12-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2007.11.002"},{"key":"bibr13-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1177\/0300985814521637"},{"key":"bibr14-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-014-0169-8"},{"key":"bibr15-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001001"},{"key":"bibr16-03009858241269836","doi-asserted-by":"publisher","DOI":"10.30802\/AALAS-CM-18-000093"},{"key":"bibr17-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9975(08)80025-4"},{"key":"bibr18-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.2003.9695141"},{"key":"bibr19-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2016.04.002"},{"key":"bibr20-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1186\/s40813-021-00207-0"},{"key":"bibr21-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1177\/1040638712452725"},{"key":"bibr22-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.11-0277"},{"key":"bibr23-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1354\/vp.44-6-936"},{"key":"bibr24-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1177\/030098589303000310"},{"key":"bibr25-03009858241269836","first-page":"206","volume":"68","author":"Pereira J","year":"1987","journal-title":"Rev Med Vet"},{"key":"bibr26-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-4-445"},{"key":"bibr27-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1530\/rep.0.1210287"},{"key":"bibr28-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1354\/vp.41-1-75"},{"key":"bibr29-03009858241269836","doi-asserted-by":"publisher","DOI":"10.2478\/v10181-010-0014-3"},{"key":"bibr30-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2007.36776"},{"key":"bibr31-03009858241269836","doi-asserted-by":"publisher","DOI":"10.2460\/javma.230.6.827"},{"key":"bibr32-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1354\/vp.38-6-661"},{"key":"bibr33-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2008.06.005"},{"key":"bibr34-03009858241269836","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci10020163"},{"key":"bibr35-03009858241269836","first-page":"147","volume":"184","author":"Wakui S","year":"1994","journal-title":"J Anat"},{"key":"bibr36-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1136\/vr.146.8.224"},{"key":"bibr37-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.1987.tb01898.x"},{"key":"bibr38-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1136\/vetreccr-2015-000267"},{"key":"bibr39-03009858241269836","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-2927.2014.00227.x"},{"key":"bibr40-03009858241269836","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1096494"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03009858241269836","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03009858241269836","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03009858241269836","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:05:36Z","timestamp":1777662336000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03009858241269836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,16]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1177\/03009858241269836"],"URL":"https:\/\/doi.org\/10.1177\/03009858241269836","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,16]]}}}