{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:32:34Z","timestamp":1777919554045,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T00:00:00Z","timestamp":1733529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>A congenital neurologic disorder affected a herd of Tabapu\u00e3 cattle. Of 98 newborn calves, 12 (12%) were affected; they were sired by 3 related bulls. This frequency suggested a genetic disorder caused by an autosomal recessive gene. Persisting recumbency, an altered sensorium, head tilt, nystagmus, episodic head and neck jerking, ventral strabismus, and opisthotonic posturing resulted in euthanasia by day 15. The postmortem findings were similar in 8 calves studied. The skull was smaller and flattened compared with unaffected calves. The cerebral hemispheres were slightly reduced in size with their gyral pattern simplified and showing occasional, focal macrogyria. The corpus callosum was partly aplastic. The pons held the most striking gross abnormality, namely, the absence of the pontine base and middle cerebellar peduncles while the trapezoid body in the medulla was reduced. There was severe hypoplasia of pontocerebellar fibers and a mildly reduced size of spinothalamic, corticospinal, and corticobulbar tracts. Histologically, numbers of neurons in the pontine basal, red, olivary, and cerebellar nuclei were reduced. Neurologic signs reflect these extensive pathologic changes, especially in the midbrain, brainstem, and caudal fossa. While olivopontocerebellar anomalies are known in domestic animals, selective pontine hypoplasia has not been reported. These Tabapu\u00e3 calves share features of pontocerebellar hypoplasia (PCH), a human malformation, in which the pons and the cerebellum are most severely affected with impaired growth of other parts of the brain leading eventually to microcephaly. At least, 11 different forms of human PCH are related to mutations in several different genes.<\/jats:p>","DOI":"10.1177\/03009858241300552","type":"journal-article","created":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T05:59:12Z","timestamp":1733551152000},"page":"532-538","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Hereditary pontine and extrapontine brain malformations in Brazilian Tabapu\u00e3 cattle"],"prefix":"10.1177","volume":"62","author":[{"given":"Lucas da Costa","family":"Dutra","sequence":"first","affiliation":[{"name":"Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3692-9199","authenticated-orcid":false,"given":"Sara Vilar Dantas","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Barbosa de","family":"Lucena","sequence":"additional","affiliation":[{"name":"Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jefferson Filgueira","family":"Alcindo","sequence":"additional","affiliation":[{"name":"Universidade Federal Rural do Semi-\u00c1rido, Mossor\u00f3, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0008-3160","authenticated-orcid":false,"given":"Gildenor X.","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Universidade Federal de Campina Grande, Patos, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian A.","family":"Summers","sequence":"additional","affiliation":[{"name":"The University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5738-7785","authenticated-orcid":false,"given":"Franklin","family":"Riet-Correa","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia, Salvador, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,12,7]]},"reference":[{"key":"e_1_3_2_2_2","volume-title":"de Lahunta\u2019s Veterinary Neuroanatomy and Clinical Neurology","author":"de Lahunta A","year":"2021","unstructured":"de Lahunta A, Glass E, Kent M. de Lahunta\u2019s Veterinary Neuroanatomy and Clinical Neurology. 5th ed. 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S\u00e3o Paulo, Brazil: Medvet; 2023:3\u201353.","edition":"4"},{"key":"e_1_3_2_10_2","first-page":"527","volume-title":"Veterinary Neuropathology","author":"Summers BA","unstructured":"Summers BA, Cummings JF, de Lahunta A. Veterinary Neuropathology. 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