{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:32:44Z","timestamp":1777919564156,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:00:00Z","timestamp":1737158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"japan society for the promotion of science","doi-asserted-by":"publisher","award":["JSPS; grant number 21H02368"],"award-info":[{"award-number":["JSPS; grant number 21H02368"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>\n                    <jats:italic>Coiled-coil domain containing 85c<\/jats:italic>\n                    (\n                    <jats:italic>Ccdc85c<\/jats:italic>\n                    ) is a causative gene for genetic hydrocephalus found in hemorrhagic hydrocephalus (\n                    <jats:italic>hhy<\/jats:italic>\n                    ) mice. The\n                    <jats:italic>Ccdc85c<\/jats:italic>\n                    knockout (KO) rat has subcortical heterotopia with frequent brain hemorrhage as seen in\n                    <jats:italic>hhy<\/jats:italic>\n                    mice. In this study, we report aberrant alpha-smooth muscle actin (\u03b1-SMA) expression in the wall of lateral ventricle of the\n                    <jats:italic>Ccdc85c<\/jats:italic>\n                    KO rats. The \u03b1-SMA-positive cells were distributed at the dorsal, medial, and lateral regions of the lateral ventricle of KO rats. The expression of \u03b1-SMA was first observed on postnatal day 20 (P20) and became noticeably stronger at P26 when hydrocephalus was prominent. Double immunofluorescence showed co-expression of \u03b1-SMA with nestin, vimentin, and glial fibrillary acidic protein in the ventricular lining of KO rats. Therefore, we conclude that \u03b1-SMA-positive cells may represent an immature subpopulation of cells at adult age around the lateral ventricle of\n                    <jats:italic>Ccdc85c<\/jats:italic>\n                    KO rats.\n                  <\/jats:p>","DOI":"10.1177\/03009858241312611","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T04:41:28Z","timestamp":1737175288000},"page":"364-370","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Aberrant alpha-smooth muscle actin expression in the lateral ventricle of\n                    <i>Ccdc85C<\/i>\n                    knockout rats"],"prefix":"10.1177","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6738-7719","authenticated-orcid":false,"given":"Nure","family":"Jannat","sequence":"first","affiliation":[{"name":"Osaka Metropolitan University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Mehedi","family":"Hasan","sequence":"additional","affiliation":[{"name":"Osaka Metropolitan University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisaki","family":"Tokuno","sequence":"additional","affiliation":[{"name":"Osaka Metropolitan University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyuu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Osaka Metropolitan University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3236-6050","authenticated-orcid":false,"given":"Takeshi","family":"Izawa","sequence":"additional","affiliation":[{"name":"Osaka Metropolitan University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyoji","family":"Yamate","sequence":"additional","affiliation":[{"name":"Osaka Metropolitan University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Kuwamura","sequence":"additional","affiliation":[{"name":"Osaka Metropolitan University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-018-2794-z"},{"issue":"4","key":"e_1_3_3_3_2","first-page":"7","article-title":"Alpha-smooth muscle actin (\u03b1-SMA)","volume":"4","author":"Cherng S","year":"2008","unstructured":"Cherng S, Young J, Ma H. Alpha-smooth muscle actin (\u03b1-SMA). 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The definition and classification of hydrocephalus: a personal recommendation to stimulate debate. Fluids Barriers CNS. 2008;5(2):1\u20137.","journal-title":"Fluids Barriers CNS"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-0992-6"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.107.6.2575"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37620-5"},{"key":"e_1_3_3_27_2","first-page":"823","article-title":"Ccdc85c, a causative protein for hydrocephalus and subcortical heterotopia, is expressed in the systemic epithelia with proliferative activity in rats","volume":"30","author":"Tanaka N","year":"2015","unstructured":"Tanaka N, Izawa T, Takenaka S, et al. Ccdc85c, a causative protein for hydrocephalus and subcortical heterotopia, is expressed in the systemic epithelia with proliferative activity in rats. 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