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This retrospective study describes the histopathological and immunohistochemical characteristics and associated clinical signs and outcomes of laryngeal and tracheal EMPs in dogs. Five tracheal and 5 laryngeal EMPs were diagnosed at the Penn Vet Diagnostic Laboratory. Clinical information was obtained via submission forms and follow-up questionnaires. All dogs were male (9 castrated), 7 to 15 years old, and of different breeds. Neoplasms were composed of well-differentiated (n = 6) or moderately differentiated (n = 4) neoplastic plasma cells arranged in sheets, cords, and packets. All neoplasms labeled positively for MUM-1, negatively for PAX5, and were variably CD20- and CD79b-positive. There was no recurrence or disease progression 2 months to 7 years post biopsy in 6\/9 cases. Results suggest that surgical resection can result in positive outcomes. 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