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In this study, we investigated the expression of \u0394Np63 in normal and neoplastic tissues of cats and compared the results with the expression of pan-p63. Immunohistochemistry for \u0394Np63 and pan-p63 was performed in normal tissues from 2 adult cats and in 10 cases each of 22 different types of feline neoplasms. In normal tissues, there was nuclear \u0394Np63 immunolabeling in basal cells of stratified squamous, transitional, and pseudostratified columnar epithelia; basal cells of sebaceous glands; trophoblasts; and myoepithelial cells. Of the neoplasms, 10\/10 apocrine ductal adenomas, 10\/10 mammary ductal carcinomas, 10\/10 pulmonary adenosquamous carcinomas, 10\/10 squamous cell carcinomas, 10\/10 trichoblastomas, and 10\/10 urothelial carcinomas immunolabeled for \u0394Np63. The \u0394Np63 immunolabeling was diffuse in almost all neoplastic cells with squamous, basal, and urothelial origins. In the neoplasms with ductal differentiation, only the neoplastic suprabasal myoepithelial cells immunolabeled. Application of pan-p63 to the same set of neoplasms revealed positivity not only in the same neoplasms, but also in several unexpected tumor types (3\/10 exocrine pancreatic carcinomas, 3\/10 fibrosarcomas, 3\/10 pulmonary adenocarcinomas, 2\/10 lymphomas, 1\/10 cholangiocarcinomas, 1\/10 hemangiosarcomas, 1\/10 mast cell tumors, and 1\/10 meningiomas). Both \u0394Np63 and pan-p63 antibodies demonstrated 100% diagnostic sensitivity and negative predictive value for diagnosing feline neoplasms with squamous, basal, and urothelial epithelia or myoepithelial cells. However, \u0394Np63 showed higher diagnostic specificity (100% vs. 90.6%), positive predictive value (100% vs. 80%), and overall accuracy (100% vs. 93.1%) compared with pan-p63.<\/jats:p>","DOI":"10.1177\/03009858251409220","type":"journal-article","created":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T10:16:25Z","timestamp":1768126585000},"page":"604-613","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Immunohistochemical expression of \u0394Np63 versus pan-p63 in normal and neoplastic feline tissues"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4247-7478","authenticated-orcid":false,"given":"Igor R.","family":"Santos","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"},{"name":"University of Guelph, Guelph, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina B.","family":"Brunner","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena C.","family":"Paz","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8740-3053","authenticated-orcid":false,"given":"Gabriela","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1474-5975","authenticated-orcid":false,"given":"Gabrielle Z.","family":"Tres","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Sonne","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0798-3594","authenticated-orcid":false,"given":"Welden","family":"Panziera","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Driemeier","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8585-6956","authenticated-orcid":false,"given":"Marcele B.","family":"Bandinelli","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8980-6294","authenticated-orcid":false,"given":"Saulo P.","family":"Pavarini","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,11]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.4132\/jptm.2018.08.14"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12388"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.38-6-657"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000204"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2021.01.013"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.08-VP-0128-C-FL"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.173"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2023.01.008"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-121808-102117"},{"key":"e_1_3_3_11_2","first-page":"602","volume-title":"Tumors in Domestic Animals","author":"Cullen JM","year":"2017","unstructured":"Cullen JM. 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