{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:43:25Z","timestamp":1782895405139,"version":"3.54.5"},"reference-count":49,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:00:00Z","timestamp":1768608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>\n                    Diagnosis and classification of ovarian epithelial neoplasms in guinea pigs (\n                    <jats:italic toggle=\"yes\">Cavia porcellus<\/jats:italic>\n                    ) are challenging due to inconsistent terminology and few available diagnostic criteria. This study evaluated 23 ovarian epithelial neoplasms in 15 guinea pigs with the objectives of (1) differentiating ovarian surface epithelial (OSE) neoplasms from rete ovarii neoplasms using immunohistochemistry, (2) describing salient histologic features, and (3) classifying neoplasms according to canine, human, and rodent classification schemes. PAX-8 immunohistochemistry separated immunoreactive rete neoplasms from nonreactive OSE neoplasms. OSE neoplasms (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 12) were well-differentiated and arose directly from the ovarian surface, rather than the primarily cortical location of OSE neoplasms in other species. Focal OSE neoplasms with papillary projections on a fibrous core or tubules within a fibrous stroma were classified as surface papilloma and surface adenoma, respectively. Generalized OSE neoplasms with tubules, papillae, and fibrous stroma were classified as surface borderline tumors. Neoplasms with invasion, 2\u20134 mitotic figures per 2.37 mm\n                    <jats:sup>2<\/jats:sup>\n                    , and\/or peritoneal implantation were classified as surface carcinoma. The only carcinoma with follow-up had resolution of clinical signs and no radiologic evidence of recurrence 6 months after ovariohysterectomy. Rete neoplasms (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 11) included rete cystadenomas and rete adenomas, and consisted of epithelial cells arranged in papillae and tubules within a rete tubule, with or without cysts, respectively. Further investigation is needed to correlate diagnoses with neoplasms\u2019 biologic behavior. We propose using \u201csurface\u201d and \u201crete\u201d in the diagnosis to denote location, rather than \u201cpapillary,\u201d \u201ccystic,\u201d or \u201cserous,\u201d which are variably used in other ovarian neoplasia classification schemes, to standardize terminology.\n                  <\/jats:p>","DOI":"10.1177\/03009858251415314","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T09:20:18Z","timestamp":1768641618000},"page":"631-641","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Spontaneous ovarian epithelial neoplasms in guinea pigs (\n                    <i>Cavia porcellus<\/i>\n                    )"],"prefix":"10.1177","volume":"63","author":[{"given":"Emily K.","family":"Swan","sequence":"first","affiliation":[{"name":"Joint Pathology Center, Silver Spring, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Foster","sequence":"additional","affiliation":[{"name":"University of Guelph, Guelph, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Garner","sequence":"additional","affiliation":[{"name":"Northwest ZooPath, Monroe, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin M.","family":"Culligan","sequence":"additional","affiliation":[{"name":"Joint Pathology Center, Silver Spring, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siobhan","family":"O\u2019Sullivan","sequence":"additional","affiliation":[{"name":"University of Guelph, Guelph, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8510-1051","authenticated-orcid":false,"given":"Elise E. B.","family":"LaDouceur","sequence":"additional","affiliation":[{"name":"Joint Pathology Center, Silver Spring, MD, USA"},{"name":"Northwest ZooPath, Monroe, WA, USA"},{"name":"Zoetis Reference Pathology, Parsippany, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,17]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.03.017"},{"key":"e_1_3_3_3_2","first-page":"689","volume-title":"Tumors of Domestic Animals","author":"Agnew DW","year":"2017","unstructured":"Agnew DW, MacLachlan NJ. Tumors of the genital system. In: Meuten DJ, ed. Tumors of Domestic Animals. 5th ed. Hoboken, NJ: John Wiley & Sons, Inc; 2017:689\u2013722.","edition":"5"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0531.2006.00812.x"},{"key":"e_1_3_3_5_2","volume-title":"Color Atlas of Veterinary Histology","author":"Bacha WJ","year":"2012","unstructured":"Bacha WJ, Bacha LM. Color Atlas of Veterinary Histology. 3rd ed. Hoboken, NJ: Wiley-Blackwell; 2012.","edition":"3"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1290\/1071-2690(2000)036<0657:ESOOSE>2.0.CO;2"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvex.2013.05.008"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/10406387241288642"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2018.09.001"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.08.052"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.218.726"},{"issue":"5","key":"e_1_3_3_12_2","first-page":"5871","article-title":"PAX-8 is a potential marker for the diagnosis of primary epithelial ovarian cancer","volume":"14","author":"Chai H","year":"2017","unstructured":"Chai H, Ren Q, Fan Q, et al. PAX-8 is a potential marker for the diagnosis of primary epithelial ovarian cancer. Oncol Lett. 2017;14(5):5871\u20135875.","journal-title":"Oncol Lett"},{"key":"e_1_3_3_13_2","first-page":"31","volume-title":"Female Genital Tumours","author":"Cheung AN","year":"2020","unstructured":"Cheung AN, Ellenson LH, Gilks CB, et al. Tumours of the ovary. In: WHO Classification of Tumours, ed. Female Genital Tumours. 5th ed. vol 4. International Agency for Research on Cancer; 2020: 31\u2013168.","edition":"5"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318033e7a8"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ilar\/ilab022"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1293\/tox.27.1S"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2024.05.006"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/56.2.293"},{"issue":"2","key":"e_1_3_3_19_2","first-page":"199","article-title":"An ovarian teratoma in a guinea pig","volume":"28","author":"Frisk CS","year":"1978","unstructured":"Frisk CS, Wagner JE, Doyle RE. An ovarian teratoma in a guinea pig. Lab Anim Sci. 1978;28(2):199\u2013201.","journal-title":"Lab Anim Sci"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-024-03872-y"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvex.2004.04.009"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-024-02049-y"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1258\/002367780780942999"},{"issue":"7","key":"e_1_3_3_24_2","first-page":"563","article-title":"Granulosa cell tumor in a guinea pig","volume":"47","author":"Jain SK","year":"1970","unstructured":"Jain SK, Singh DK, Rao UR. Granulosa cell tumor in a guinea pig. Indian Vet J. 1970;47(7):563\u2013564.","journal-title":"Indian Vet J"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098588702400408"},{"key":"e_1_3_3_26_2","first-page":"1","volume-title":"World Health Organization International Histological Classification of Tumors of Domestic Animals","author":"Kennedy PC","year":"1998","unstructured":"Kennedy PC, Cullen JM, Edwards JF, et al. Histological classification of tumors of the genital system of domestic animals. In: Schulman FY, ed. World Health Organization International Histological Classification of Tumors of Domestic Animals. 2nd series. vol 4. Armed Forces Institute of Pathology; 1998:1\u201379."},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2017.03.002"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.2754\/avb201786030269"},{"key":"e_1_3_3_29_2","volume-title":"Reproductive Pathology of Domestic Animals","author":"McEntee K.","year":"1990","unstructured":"McEntee K. Reproductive Pathology of Domestic Animals. Cambridge, MA: Academic Press; 1990."},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.103053"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.2754\/avb202392040375"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098588001700215"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200302000-00005"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pap.0000201832.15591.1d"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(72)90014-2"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2024.07.002"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvex.2013.09.003"},{"issue":"3","key":"e_1_3_3_38_2","first-page":"337","article-title":"Serous cystadeoma formation in guinea pig ovaries","volume":"13","author":"Quattropani SL.","year":"1981","unstructured":"Quattropani SL. Serous cystadeoma formation in guinea pig ovaries. J Submicrosc Cytol. 1981;13(3):337\u2013345.","journal-title":"J Submicrosc Cytol"},{"key":"e_1_3_3_39_2","first-page":"191","article-title":"Studies of guinea pigs tumors. I. Report of fourteen spontaneous guinea pig tumors with a review of the literature","volume":"20","author":"Rogers JB","year":"1960","unstructured":"Rogers JB, Blumenthal HT. Studies of guinea pigs tumors. I. Report of fourteen spontaneous guinea pig tumors with a review of the literature. Cancer Res. 1960;20:191\u2013197.","journal-title":"Cancer Res"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvex.2024.07.004"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1998.5153"},{"issue":"9","key":"e_1_3_3_42_2","first-page":"879","article-title":"The induction of benign epithelial neoplasms of the ovaries in guinea pigs by testosterone stimulation: a potential animal model","volume":"10","author":"Silva EG","year":"1997","unstructured":"Silva EG, Tornos C, Fritsche HA, et al. The induction of benign epithelial neoplasms of the ovaries in guinea pigs by testosterone stimulation: a potential animal model. Mod Pathol. 1997;10(9):879\u2013883.","journal-title":"Mod Pathol"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e3182025f66"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-45024-2"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.30704\/http-www-jivs-net.999648"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-1-67"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1177\/1040638716665429"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13092278"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711020310"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700840129"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03009858251415314","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03009858251415314","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03009858251415314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:43:41Z","timestamp":1782891821000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03009858251415314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,17]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/03009858251415314"],"URL":"https:\/\/doi.org\/10.1177\/03009858251415314","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,17]]}}}