{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T11:52:59Z","timestamp":1781783579341,"version":"3.54.5"},"reference-count":35,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100023663","name":"American College of Laboratory Animal Medicine","doi-asserted-by":"publisher","award":["Foundation Grant"],"award-info":[{"award-number":["Foundation Grant"]}],"id":[{"id":"10.13039\/100023663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["Cancer Center Support Grant P30 CA008748"],"award-info":[{"award-number":["Cancer Center Support Grant P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    Mouse kidney parvovirus (MKPV) causes inclusion body nephropathy, resulting in clinical signs and mortality in immunodeficient mice and subclinical infection in immunocompetent mice. While late-stage renal lesions and viral replication have been characterized, a comprehensive multisystemic investigation of MKPV infection from the initial to the late stages of infection has not been conducted. Our goal was to investigate lesions and viral replication in all major organs at multiple stages of MKPV infection in immunocompetent C57BL\/6NCrl (B6) and Crl: CD1(ICR) (CD1) mice and immunodeficient NOD. Cg-\n                    <jats:italic toggle=\"yes\">Prkdc<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic toggle=\"yes\">scid<\/jats:italic>\n                    <\/jats:sup>\n                    <jats:italic toggle=\"yes\">Il2rg<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic toggle=\"yes\">tm1Wjl<\/jats:italic>\n                    <\/jats:sup>\n                    \/SzJ (NSG) mice. Following experimental oronasal inoculation with MKPV, mice were evaluated at 15 time points from 1.5 to 112 days post-inoculation (DPI) by histology and\n                    <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                    hybridization for MKPV RNA on all major organs, as well as immunohistochemistry for markers of immune cells and renal tubular injury. In all strains, the gastrointestinal mucosa was the initial site of viral replication beginning at 3 DPI and persisting through the study without associated lesions. In B6 and CD1 mice, viral replication was first detected in renal tubules on 28 and 14 DPI, respectively, and lymphoplasmacytic tubulointerstitial nephritis was first evident on 63 and 49 DPI, respectively. B6 mice displayed the lowest levels of renal viral replication and lesion severity. In contrast, renal viral replication was highest in NSG mice; the virus was first detected on 42 DPI and in association with tubular degeneration from 63 DPI. Electron microscopy on kidney tissues of infected mice revealed parvoviral virions, nuclear replication, and assembly compartments for the first time.\n                  <\/jats:p>","DOI":"10.1177\/03009858261420394","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T18:28:26Z","timestamp":1773253706000},"page":"542-560","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Ultrastructural pathology and temporal patterns of viral replication and lesion development following mouse kidney parvovirus infection in B6, CD1, and NSG mice"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3168-0515","authenticated-orcid":false,"given":"Ileana C.","family":"Miranda","sequence":"first","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, and The Rockefeller University, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy L.","family":"Kain","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, and The Rockefeller University, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda C.","family":"Ritter","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, and The Rockefeller University, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8917-4810","authenticated-orcid":false,"given":"Rodolfo J. R.","family":"Arbona","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, and The Rockefeller University, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1870-9945","authenticated-orcid":false,"given":"Anibal G.","family":"Armien","sequence":"additional","affiliation":[{"name":"University of California, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1258-2602","authenticated-orcid":false,"given":"Neil S.","family":"Lipman","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, and The Rockefeller University, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2841-6887","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Monette","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, and The Rockefeller University, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/03009858231180488"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000126"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003605"},{"key":"e_1_3_3_5_2","first-page":"435","article-title":"Karyomegaly and intranuclear inclusions in the renal tubules of sentinel ICR mice (mus musculus)","volume":"56","author":"Baze WB","year":"2006","unstructured":"Baze WB, Steinbach TJ, Fleetwood ML, et al. Karyomegaly and intranuclear inclusions in the renal tubules of sentinel ICR mice (mus musculus). Comp Med. 2006;56:435\u2013438.","journal-title":"Comp Med"},{"key":"e_1_3_3_6_2","first-page":"66","article-title":"Temporal transmission studies of mouse parvovirus 1 in BALB\/c and C.B-17\/Icr-Prkdc(scid) mice","volume":"57","author":"Besselsen DG","year":"2007","unstructured":"Besselsen DG, Becker MD, Henderson KS, et al. Temporal transmission studies of mouse parvovirus 1 in BALB\/c and C.B-17\/Icr-Prkdc(scid) mice. Comp Med. 2007;57:66\u201373.","journal-title":"Comp Med"},{"key":"e_1_3_3_7_2","first-page":"498","article-title":"Effect of mouse strain and age on detection of mouse parvovirus 1 by use of serologic testing and polymerase chain reaction analysis","volume":"50","author":"Besselsen DG","year":"2000","unstructured":"Besselsen DG, Wagner AM, Loganbill JK. 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