{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T07:28:10Z","timestamp":1793518090028,"version":"4.5.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Faculty of Veterinary Science, Mahidol University","id":[{"id":"https:\/\/ror.org\/01znkr924","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:p>\n                    Feline mammary carcinomas (FMCs) are heterogeneous neoplasms often comprising multiple histological patterns within a single case. The current practice of focusing on a prominent subtype hinders prognostic accuracy and potentially produces suboptimal therapeutic decisions. This retrospective study proposed criteria for grouping these mixed patterns and evaluated their prognostic significance in FMCs. The criteria were based on the tubular carcinoma composition and adopted from those of human breast cancer. Eighty-seven cats with FMCs were divided into groups according to tubular carcinoma composition: pure tubular carcinoma (PTC,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 34), tubular carcinoma mixed with other subtypes (TMC,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 16), and nontubular carcinoma (NTC,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 37). Prognostic factors and overall survival (OS) were compared among the groups. The PTC and TMC groups were significantly associated with early-stage FMCs (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .03) and low argyrophilic nucleolar organizer region values (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .02). Conversely, NTCs had the poorest prognosis (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .03) and were associated with incomplete surgical margins (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .004), advanced clinical stage (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001), and high histological grade (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001) on multivariable analysis. Median OS for the PTC, TMC, and NTC groups was 221, 242, and 147 days, respectively. Considering individual histological subtypes, cats with adenosquamous carcinoma had a shorter OS (60 days) than those with comedocarcinoma (147 days) and tubular carcinoma (240 days,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001). These criteria were associated with FMC outcome in this cohort, providing a potentially useful framework for prognosis. However, further validation through prospective studies is needed to fully establish their clinical utility.\n                  <\/jats:p>","DOI":"10.1177\/03009858261462564","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:13:37Z","timestamp":1783944817000},"page":"1025-1037","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathological characteristics and clinical outcomes of multiple histological subtypes in feline mammary carcinomas"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3926-9618","authenticated-orcid":false,"given":"Pruettha","family":"Aruvornlop","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Science, Mahidol University, Nakhon Pathom, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9061-4270","authenticated-orcid":false,"given":"Nlin","family":"Arya","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science, Mahidol University, Nakhon Pathom, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5809-6936","authenticated-orcid":false,"given":"Sirintra","family":"Sirivisoot","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1895-8992","authenticated-orcid":false,"given":"Tanit","family":"Kasantikul","sequence":"additional","affiliation":[{"name":"Veterinary Diagnostic Laboratory, Michigan State University, East Lansing, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rassameepen","family":"Phonarknguen","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science, Mahidol University, Nakhon Pathom, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8245-9506","authenticated-orcid":false,"given":"Walasinee","family":"Sakcamduang","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science, Mahidol University, Nakhon Pathom, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.11606\/issn.1678-4456.bjvras.2018.135084"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(98)90002-9"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2019.00387"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300985819846870"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjbas.2018.06.011"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X15610367"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.252.11.1393"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810393258"},{"key":"e_1_3_4_10_2","first-page":"723","volume-title":"Tumors in Domestic Animals","author":"Goldschmidt MH","year":"2017","unstructured":"Goldschmidt MH, Pe\u00f1a L, Zappulli V. Tumors of the mammary gland. In Meuten DJ, ed. Tumors in Domestic Animals. 5th ed. Ames, IA: John Wiley; 2017:723\u2013765.","edition":"5"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300985816650243"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/bcr444"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2012.05.008"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-1-120"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300985814543198"},{"key":"e_1_3_4_16_2","volume-title":"Histologic Classification of Mammary Tumors of the Dog and the Cat","author":"Misdorp W","year":"1999","unstructured":"Misdorp W, Else RW, Hellmen E, et al. Histologic Classification of Mammary Tumors of the Dog and the Cat. Second series, vol vii. Armed Forces Institute of Pathology in cooperation with the American Registry of Pathology and the World Health Organization Collaborating Center for Worldwide Reference on Comparative Oncology; 1999."},{"issue":"1","key":"e_1_3_4_17_2","first-page":"117","article-title":"Histological characterization of some feline mammary gland tumors with whole slide images scan as a trial of remote diagnosis","volume":"9","author":"Mohamed Ali M","year":"2020","unstructured":"Mohamed Ali M, Hassan B, Mokaddem A, et al. Histological characterization of some feline mammary gland tumors with whole slide images scan as a trial of remote diagnosis. 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