{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:34:06Z","timestamp":1777919646079,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1965,3,1]],"date-time":"1965-03-01T00:00:00Z","timestamp":-152668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathologia veterinaria"],"published-print":{"date-parts":[[1965,3]]},"abstract":"<jats:p>\n                    A study was made of the fine structure of the hepatocytes of 5 sheep affected with mild to severe lantana poisoning of from 1 to 7 days duration. For comparative purposes, observations were also made of the livers of both well fed and starved normal sheep and a CCl\n                    <jats:sub>4<\/jats:sub>\n                    poisoned sheep 24 hours after dosing. The earliest and most consistent alteration of the fine structure of the hepatocytes in lantana poisoning was a characteristic separation of the interface plasma membranes with extensive formation of microvilli without significant cytoplasmic changes. This lesion is thought to be characteristic of this type of liver injury. In more severely affected livers, bile canalicular changes were accompanied by marked nuclear and cytoplasmic changes in many hepatocytes. These latter changes however, were considered to be mainly secondary and associated with the retention and regurgitation of bile.\n                  <\/jats:p>","DOI":"10.1177\/030098586500200206","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T21:12:43Z","timestamp":1498857163000},"page":"175-196","source":"Crossref","is-referenced-by-count":8,"title":["Electron Microscopic Observations of the Hepatocytes of Sheep in Lantana Poisoning"],"prefix":"10.1177","volume":"2","author":[{"given":"A. A.","family":"Seawright","sequence":"first","affiliation":[{"name":"From the Department of Preventive Medicine, Veterinary School, University of Queensland, Brisbane"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1965,3]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001100102"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(60)90160-9"},{"key":"e_1_2_2_4_1","first-page":"1099","article-title":"Studies on cholestasis. - The fine structure and morphogenesis of hepatocellular and canalicular bile pigment.","volume":"13","author":"Biava C.","year":"1964","unstructured":"Biava C.: Studies on cholestasis. - The fine structure and morphogenesis of hepatocellular and canalicular bile pigment. Lab. Invest. 13: 1099\u20131123 (1964)","journal-title":"Lab. 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D. Th\u00e8se de Toulouse (1960) cited by Rouiller Ch. and J\u00e9z\u00e9quel A.-M.: Electron Microscopy of the Liver Chapter 5 pp. 195 to 264 Vol. I in: The Liver Morphology Biochemistry Physiology Ed. Ch. Rouiller. (Academic Press New York and London 1963)","DOI":"10.1016\/B978-1-4832-2824-2.50011-X"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.2.4.435"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.10.1.95"},{"key":"e_1_2_2_15_1","first-page":"203","article-title":"Das electronenmikroskopische Bild der Leberparenchymzelle nach histotoxischer Hypoxydose.","volume":"118","author":"M\u00f6lbert E.","year":"1957","unstructured":"M\u00f6lbert E.: Das electronenmikroskopische Bild der Leberparenchymzelle nach histotoxischer Hypoxydose. Beitr. path. Anat. 118: 203\u2013227 (1957)","journal-title":"Beitr. path. 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