{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:06:33Z","timestamp":1787018793366,"version":"build-2736575974"},"reference-count":52,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1972,5,1]],"date-time":"1972-05-01T00:00:00Z","timestamp":73526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[1972,5]]},"abstract":"<jats:p>The microscopic structure of canine carotid and aortic body neoplasms was compared with that of other lesions of the neck and thorax. Carotid and aortic body adenomas consisted of clusters of large, polyhedral cells whose cytoplasm was filled with dense, membrane-bound granules and which lacked the normal relationship to sustentacular, nerve, and vascular cells. Unlike an ectopic thyroid adenoma, they had no thyroid follicles, PAS-stained cytoplasmic granules, acidic mucopolysaccharide foci, or dense tubules within the cisternae of the endoplasmic reticulum. Cells of the aortic body carcinoma were less differentiated than those of the adenoma. They contained fewer dense granules but had greater numbers of microfibrils and Golgi vesicles. Degeneration and necrosis of neoplastic tissue exaggerated differences from the adenomas. Cells from the metastatic tumor (pleural carcinomatosis) did not differ significantly from those of the primary tumor. Cells from thyroid and parathyroid lesions were significantly different ultrastructurally from those of carotid and aortic body tumors. Cells of the ectopic thyroid adenoma and thyroid carcinoma resembled normal follicular cells but were larger and contained characteristic PAS-stained granules and arrays of intracisternal microtubules. The parathyroid adenoma cells had few organelles; the dominant cytoplasmic structures were aggregates of membranes and residual bodies filled with lipofuscin.<\/jats:p>","DOI":"10.1177\/030098587200900301","type":"journal-article","created":{"date-parts":[[2010,3,8]],"date-time":"2010-03-08T17:26:15Z","timestamp":1268069175000},"page":"166-189","source":"Crossref","is-referenced-by-count":45,"title":["Ultrastructure of Canine Carotid Body and Aortic Body Tumors Comparison with Tissues of Thyroid and Parathyroid Origin"],"prefix":"10.1177","volume":"9","author":[{"given":"N. F.","family":"Cheville","sequence":"first","affiliation":[{"name":"National Animal Disease Laboratory, USDA, Ames, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1972,5]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"The comparative morphology of the carotid body and carotid sinus","author":"Adams W. E.","year":"1958","unstructured":"Adams W. E.: The comparative morphology of the carotid body and carotid sinus (Thomas, Springfield 1958)."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.30.3.563"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1967.sp001882"},{"key":"e_1_2_1_5_1","first-page":"1","article-title":"Structure and histogenesis of tumors of the aortic bodies in dogs with a consideration of the morphology of the aortic and carotid bodies.","volume":"36","author":"Bloom F.","year":"1943","unstructured":"Bloom F.: Structure and histogenesis of tumors of the aortic bodies in dogs with a consideration of the morphology of the aortic and carotid bodies. Arch. Path. 36: 1\u201312 (1943).","journal-title":"Arch. Path."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00541014"},{"key":"e_1_2_1_7_1","unstructured":"Braun O.: Ein Betragzur Kenntnis der Herzbasisgeschwulste beim Hund; Inaug. Diss. Leipzig."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196808)22:2<406::AID-CNCR2820220219>3.0.CO;2-B"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098586800500111"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0370205"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02892077"},{"key":"e_1_2_1_12_1","first-page":"683","article-title":"Beitrag zur Kenntnis der intraperikardialen akzessorischen Schilddr\u00fcsen und Epithelk\u00f6rperchen beim Hund (Canis familiaris). Tier\u00e4rztl.","volume":"46","author":"Cohrs P.","year":"1930","unstructured":"Cohrs P.: Beitrag zur Kenntnis der intraperikardialen akzessorischen Schilddr\u00fcsen und Epithelk\u00f6rperchen beim Hund (Canis familiaris). Tier\u00e4rztl. Wschr., Berl. 46: 683\u2013688 (1930).","journal-title":"Wschr., Berl."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1937.121.1.75"},{"key":"e_1_2_1_14_1","unstructured":"Cotchin E.: Neoplasms of the domesticated animals. A review. Commonwlth Bur. An. Hlth Rev. Ser. No. 4 pp. 21 22 (1956)."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711040404"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(71)80077-1"},{"issue":"56","key":"e_1_2_1_17_1","article-title":"Observations on the possibility of the cellular localization of monoamines by a fluorescent method.","volume":"197","author":"Falck B.","year":"1962","unstructured":"Falck B.: Observations on the possibility of the cellular localization of monoamines by a fluorescent method. Acta physiol. scand. 56: suppl., vol. 197 (1962).","journal-title":"Acta physiol. scand."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196709)20:9<1473::AID-CNCR2820200914>3.0.CO;2-I"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00339756"},{"key":"e_1_2_1_20_1","first-page":"1121","article-title":"Neoplasia of the boxer dog.","volume":"26","author":"Howard E. B.","year":"1965","unstructured":"Howard E. B., Nielsen S. W.: Neoplasia of the boxer dog. Amer. J. vet. Res. 26: 1121\u20131131 (1965).","journal-title":"Amer. J. vet. Res."},{"key":"e_1_2_1_21_1","first-page":"411","article-title":"Carotid body tumor in the dog.","volume":"137","author":"Hubben K.","year":"1960","unstructured":"Hubben K., Patterson D. F., Detweiler D. K.: Carotid body tumor in the dog. J. amer. vet. med. Ass. 137: 411\u2013416 (1960).","journal-title":"J. amer. vet. med. Ass."},{"key":"e_1_2_1_22_1","first-page":"1","article-title":"The incidence and pathology of tumours of domestic animals in South Africa. A study of the Onderstepoort collection of neoplasms with special reference to their histopathology. Onderst.","volume":"6","author":"Jackson C.","year":"1936","unstructured":"Jackson C.: The incidence and pathology of tumours of domestic animals in South Africa. A study of the Onderstepoort collection of neoplasms with special reference to their histopathology. Onderst. J. vet. Sci. 6: 1\u2013460 (1936).","journal-title":"J. vet. Sci."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195701\/02)10:1<89::AID-CNCR2820100112>3.0.CO;2-K"},{"key":"e_1_2_1_24_1","first-page":"340","volume-title":"Pathology of domestic animals","author":"Jubb K. V. F.","year":"1963","unstructured":"Jubb K. V. F., Kennedy P. C.: Pathology of domestic animals; 1st ed., vol. 1, p. 340 (Academic Press, New York 1963).","edition":"1"},{"key":"e_1_2_1_25_1","first-page":"41","article-title":"The relationship of ultimobranchial remnants of the thyroid gland in cattle.","volume":"49","author":"Jubb K. V.","year":"1959","unstructured":"Jubb K. V., McEntee K.: The relationship of ultimobranchial remnants of the thyroid gland in cattle. Cornell Vet. 49: 41\u201369 (1959).","journal-title":"Cornell Vet."},{"key":"e_1_2_1_26_1","first-page":"459","article-title":"Herzbasistumoren beim Hund.","volume":"5","author":"Kast A.","year":"1958","unstructured":"Kast A.: Herzbasistumoren beim Hund. Zbl. VetMed. 5: 459\u2013474 (1958).","journal-title":"Zbl. VetMed."},{"key":"e_1_2_1_27_1","first-page":"109","article-title":"Morphologisch-experimenteller Beitrag zur Kenntnis der Glomus caroticum.","volume":"83","author":"Knoche H.","year":"1971","unstructured":"Knoche H., Decker S., Schmitt G.: Morphologisch-experimenteller Beitrag zur Kenntnis der Glomus caroticum. Z. mikr.-anat. Forsch. 83: 109\u2013137 (1971).","journal-title":"Z. mikr.-anat. Forsch."},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc1950.30.95"},{"key":"e_1_2_1_29_1","first-page":"1247","article-title":"Carotid body and aortic body tumors in a dog.","volume":"30","author":"Kurtz H. F.","year":"1969","unstructured":"Kurtz H. F., Finco D. R.: Carotid body and aortic body tumors in a dog. Amer. J. vet. Res. 30: 1247\u20131251 (1969).","journal-title":"Amer. J. vet. Res."},{"key":"e_1_2_1_30_1","volume-title":"Tumors of the carotid body and related structures. Atlas of tumor pathology, sect. IV, fascicle 16","author":"le Compte P. M.","year":"1951","unstructured":"le Compte P. M.: Tumors of the carotid body and related structures. Atlas of tumor pathology, sect. IV, fascicle 16. Armed Forces Inst. Path., Washington, D. C. (1951)."},{"key":"e_1_2_1_31_1","unstructured":"M\u2298ller-Sorensen A.: Om Stroma intrathoracica hos honden. Kgl. Veterinar og Landbohojskole Arskrift. pp. 191 206 (1919)."},{"key":"e_1_2_1_32_1","first-page":"205","article-title":"Paraganglionen bij mens en hond.","volume":"90","author":"Misdorp W. Z.","year":"1965","unstructured":"Misdorp W. Z., Elders R. A. R.: Paraganglionen bij mens en hond. T. Diergeneesk. 90: 205\u2013229 (1965).","journal-title":"T. Diergeneesk."},{"key":"e_1_2_1_33_1","first-page":"217","volume-title":"Tumors in domestic animals","author":"Moulton J. E.","year":"1961","unstructured":"Moulton J. E.: Tumors in domestic animals, pp. 217 219 (University of California Press, Berkeley 1961)."},{"key":"e_1_2_1_34_1","volume-title":"Special pathological anatomy of domestic animals","author":"Nieberle P.","year":"1967","unstructured":"Nieberle P., Cohrs P.: Special pathological anatomy of domestic animals (Pergamon Press, Oxford 1967)."},{"key":"e_1_2_1_35_1","first-page":"875","article-title":"A case of metastasizing tumour of the glomus aorticus in a dog.","volume":"8","author":"Nilsson A.","year":"1956","unstructured":"Nilsson A.: A case of metastasizing tumour of the glomus aorticus in a dog. Nord. Vet. Med. 8: 875\u2013881 (1956).","journal-title":"Nord. Vet. Med."},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1955.tb00961.x"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090690305"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196803)21:3<406::AID-CNCR2820210310>3.0.CO;2-6"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098586600300502"},{"key":"e_1_2_1_40_1","first-page":"487","article-title":"Les tumeurs des chemorecepteurs. Observations personnelles chez le chien.","volume":"57","author":"Parodi A. L.","year":"1970","unstructured":"Parodi A. L., et Lekkas S.: Les tumeurs des chemorecepteurs. Observations personnelles chez le chien. Bull. Cancer 57: 487\u2013516 (1970).","journal-title":"Bull. Cancer"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.79.21.587"},{"key":"e_1_2_1_42_1","first-page":"388","article-title":"Heart-base tumor in a dog.","volume":"30","author":"Riser W. H.","year":"1949","unstructured":"Riser W. H., Bailey L. K.: Heart-base tumor in a dog. Nth amer. Vet. 30: 388\u2013389 (1949).","journal-title":"Nth amer. Vet."},{"key":"e_1_2_1_43_1","first-page":"403","volume-title":"Principles of veterinary pathology","author":"Runnells R. A.","year":"1965","unstructured":"Runnells R. A., Monlux W. S., Monlux A. W.: Principles of veterinary pathology; 7th ed., p. 403 (Iowa State University Press, Ames 1965).","edition":"7"},{"key":"e_1_2_1_44_1","first-page":"413","article-title":"The carotid body tumor in dogs.","volume":"132","author":"Scotti T. M.","year":"1958","unstructured":"Scotti T. M.: The carotid body tumor in dogs. J. amer. vet. med. Ass. 132: 413\u2013418 (1958).","journal-title":"J. amer. vet. med. Ass."},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1159\/000142791"},{"key":"e_1_2_1_46_1","first-page":"218","volume-title":"Veterinary pathology","author":"Smith H. A.","year":"1961","unstructured":"Smith H. A., Jones T. C.: Veterinary pathology, p. 218 (Lea & Febiger, Philadelphia 1961)."},{"key":"e_1_2_1_47_1","first-page":"631","article-title":"Herzbasisgeschw\u00fclste beim Hund.","volume":"15","author":"St\u00fcnzi H.","year":"1952","unstructured":"St\u00fcnzi H.: Herzbasisgeschw\u00fclste beim Hund. Schweiz. Z. Path. 15: 631\u2013637 (1952).","journal-title":"Schweiz. Z. Path."},{"key":"e_1_2_1_48_1","first-page":"87","article-title":"Zur Histogenese der Herzbasisgeschwulste des Hundes.","volume":"1","author":"St\u00fcnzi H.","year":"1963","unstructured":"St\u00fcnzi H., Teuscher E.: Zur Histogenese der Herzbasisgeschwulste des Hundes. Zbl. VetMed 1: 87\u201392 (1963).","journal-title":"Zbl. VetMed"},{"key":"e_1_2_1_49_1","first-page":"159","article-title":"Electron microscopic observations of the cyst of ultimobranchial origin found in the thyroid gland of a dog.","volume":"25","author":"Tashiro M.","year":"1963","unstructured":"Tashiro M.: Electron microscopic observations of the cyst of ultimobranchial origin found in the thyroid gland of a dog. Nagoya J. med. Sci. 25: 159\u2013163 (1963).","journal-title":"Nagoya J. med. Sci."},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985871008005-00604"},{"key":"e_1_2_1_51_1","first-page":"99","article-title":"Tumeurs multiples du syst\u00e8me ch\u00e9mor\u00e9cepteur chez un chien.","volume":"89","author":"Tisseur H.","year":"1963","unstructured":"Tisseur H., et Parodi A.: Tumeurs multiples du syst\u00e8me ch\u00e9mor\u00e9cepteur chez un chien. Rec. M\u00e9d. v\u00e9t., Toulouse 89: 99\u2013111 (1963).","journal-title":"Rec. M\u00e9d. v\u00e9t., Toulouse"},{"key":"e_1_2_1_52_1","first-page":"59","article-title":"Intrastructure des divers types de terminaisons nerveuses dans le glomus carotid du lapin.","volume":"10","author":"Verna A.","year":"1971","unstructured":"Verna A.: Intrastructure des divers types de terminaisons nerveuses dans le glomus carotid du lapin. J. Microscopie 10: 59\u201366 (1971).","journal-title":"J. Microscopie"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.19.2.114"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098587200900301","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098587200900301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:12:00Z","timestamp":1777662720000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030098587200900301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,5]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1972,5]]}},"alternative-id":["10.1177\/030098587200900301"],"URL":"https:\/\/doi.org\/10.1177\/030098587200900301","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,5]]}}}