{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:38:47Z","timestamp":1777919927728,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1978,3,1]],"date-time":"1978-03-01T00:00:00Z","timestamp":257558400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[1978,3]]},"abstract":"<jats:p>\n                    An outbreak of severe diarrhoea and death in young rabbits was associated with many nonenterotoxigenic\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    in the caecum. The severe clinical, pathological and bacteriological features of the diesase, acute diarrhoea associated with typhlitis and many\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    in the caecum, could be reproduced either by the intraintestinal inoculation of many bacteria recovered aerobically or anaerobically from the caecum of these rabbits or by the intestinal inoculation of large numbers of a serogroup of\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    , 0153, recovered from the caecum. Further experiments showed that this serogroup of\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    , as well as a nonenteropathogenic serotype recovered from human faeces, would cause typhlitis and diarrhoea if inoculated in large numbers into the jejunum; pathological changes also were seen in the liver and kidney. Similar changes also could be induced by intravenous inoculation of a freeze-thaw (endotoxic) extract prepared from these strains. Any factor that allows rapid multiplication of\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    in the rabbit caecum may be followed by absorption of endotoxin and subsequent typhlitis and sometimes by severe diarrhoea; this effect is seen in some field cases of diarrhoea in the rabbit.\n                  <\/jats:p>","DOI":"10.1177\/030098587801500210","type":"journal-article","created":{"date-parts":[[2010,1,27]],"date-time":"2010-01-27T05:13:23Z","timestamp":1264569203000},"page":"237-248","source":"Crossref","is-referenced-by-count":19,"title":["<i>Escherichia coli<\/i>\n                    and Diarrhoea in the Rabbit"],"prefix":"10.1177","volume":"15","author":[{"given":"J. F.","family":"Prescott","sequence":"first","affiliation":[{"name":"Department of Clinical Veterinary Medicine, Madingley Road, Cambridge, England"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1978,3]]},"reference":[{"key":"e_1_2_2_2_2","first-page":"859","article-title":"Tyzzer's disease syndrome in laboratory rabbits","volume":"46","author":"Allen A.M.","year":"1965","unstructured":"Allen A.M., Gallaway J.R., Moore T.D., Kinnard R.F.: Tyzzer's disease syndrome in laboratory rabbits. Am J Pathol 46: 859\u2013882, 1965.","journal-title":"Am J Pathol"},{"key":"e_1_2_2_3_2","first-page":"93","article-title":"Ultrastructural pathology of an acute fatal enteritis of captive cottontail rabbits. Search for a viral etiologic agent","volume":"57","author":"Brown R.C.","year":"1969","unstructured":"Brown R.C., Richter C.B., Bloomer M.S.: Ultrastructural pathology of an acute fatal enteritis of captive cottontail rabbits. 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