{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:39:12Z","timestamp":1777919952709,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1978,9,1]],"date-time":"1978-09-01T00:00:00Z","timestamp":273456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[1978,9]]},"abstract":"<jats:p>\n                    Fischer 344 rats and B6C3F\n                    <jats:sub>1<\/jats:sub>\n                    mice were fed diets that contained 0.03, 0.06, 0.1 and 0.2% 4,4'-oxydianiline for 13 weeks. The 0.1 to 0.2% diet caused 40 to 70% mortality in female rats. Although mice ate about 3.5 times more chemical than rats, no mice died. Alopecia, dyspnea and cyanosis in rats, and lethargy in both species occurred in the 0.1 to 0.2% groups. Goiter was found in rats that died as early as the 4th to 5th week of study in the groups given the 0.06 to 0.1% diet. At the end of the study, diffuse parenchymatous goiter was seen in all rats given the 0.06% and higher concentration diets and in most mice given the 0.2% diet. In rats, the thyroids also were heavily encapsulated and had interstitial fibrosis and vascular degeneration. There was concomitant hyperplasia of pituitary basophils in both species, but an increase of cells that secrete thyrotropin was seen in rats only.\n                  <\/jats:p>","DOI":"10.1177\/030098587801500508","type":"journal-article","created":{"date-parts":[[2010,1,27]],"date-time":"2010-01-27T04:43:09Z","timestamp":1264567389000},"page":"649-662","source":"Crossref","is-referenced-by-count":15,"title":["The Goitrogenic Effect of 4,4'-Oxydianiline in Rats and Mice"],"prefix":"10.1177","volume":"15","author":[{"given":"D. W.","family":"Hayden","sequence":"first","affiliation":[{"name":"Departments of Pathology and Carcinogenesis, Mason Research Institute, Worcester, Mass."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. G.","family":"Wade","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Carcinogenesis, Mason Research Institute, Worcester, Mass."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. H.","family":"Handler","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Carcinogenesis, Mason Research Institute, Worcester, Mass."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1978,9,1]]},"reference":[{"key":"bibr1-030098587801500508","first-page":"69","volume":"21","author":"Dzhioev F.K.","year":"1975","journal-title":"Vopr Onkol"},{"key":"bibr2-030098587801500508","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(68)90101-4"},{"key":"bibr3-030098587801500508","first-page":"2085","volume":"276","author":"Goudard L.","year":"1973","journal-title":"CR Acad Sci [D]"},{"key":"bibr4-030098587801500508","first-page":"619","volume":"26","author":"Griswold D.P.","year":"1966","journal-title":"Cancer Res"},{"key":"bibr5-030098587801500508","first-page":"924","volume":"28","author":"Griswold D.P.","year":"1968","journal-title":"Cancer Res"},{"key":"bibr6-030098587801500508","doi-asserted-by":"publisher","DOI":"10.1007\/BF00524677"},{"key":"bibr7-030098587801500508","unstructured":"IARC: Monographs on the evaluation of carcinogenic risk of chemicals to man. 4:79\u201385, 1974; International Agency for Research on Cancer, Lyons, France"},{"key":"bibr8-030098587801500508","doi-asserted-by":"publisher","DOI":"10.1126\/science.94.2448.518"},{"key":"bibr9-030098587801500508","first-page":"187","volume-title":"Bladder Cancer","author":"Munn A.","year":"1967"},{"key":"bibr10-030098587801500508","first-page":"67","volume-title":"Public Health Service Publication","volume":"1332","author":"Russfield A.B.","year":"1966"},{"key":"bibr11-030098587801500508","first-page":"3","volume-title":"Public Health Service Publication","volume":"1332","author":"Russfield A.B.","year":"1966"},{"key":"bibr12-030098587801500508","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(75)90050-2"},{"key":"bibr13-030098587801500508","first-page":"536","volume":"48","author":"Seifter J.","year":"1949","journal-title":"Arch Pathol"},{"key":"bibr14-030098587801500508","doi-asserted-by":"publisher","DOI":"10.1007\/BF01010277"},{"key":"bibr15-030098587801500508","first-page":"380","volume":"19","author":"Stula E.F.","year":"1971","journal-title":"Toxicol Appl Pharmacol"},{"key":"bibr16-030098587801500508","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(75)90064-2"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098587801500508","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098587801500508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:16:06Z","timestamp":1777662966000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030098587801500508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,9]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1978,9]]}},"alternative-id":["10.1177\/030098587801500508"],"URL":"https:\/\/doi.org\/10.1177\/030098587801500508","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,9]]}}}