{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T22:16:26Z","timestamp":1785708986855,"version":"3.56.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"5_suppl","license":[{"start":{"date-parts":[[1978,8,1]],"date-time":"1978-08-01T00:00:00Z","timestamp":270777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[1978,8]]},"abstract":"<jats:p>Heavy metal nephropathy is a pathologic entity of the renal tubular epithelium of rats, evoked by lead, gold, and other heavy metals. It is characterized acutely by coagulative necrosis, subacutely by cortical fibrosis, and chronically by cytomegaly and karyomegaly. Finally, adenomas develop, some of which become malignant.<\/jats:p>","DOI":"10.1177\/0300985878015s0507","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T07:55:36Z","timestamp":1500364536000},"page":"51-87","source":"Crossref","is-referenced-by-count":31,"title":["Heavy Metal Nephropathy of Rodents"],"prefix":"10.1177","volume":"15","author":[{"given":"B. J.","family":"Payne","sequence":"first","affiliation":[{"name":"Department of Pathology and Toxicology, Smith Kline & French Laboratories, Philadelphia, Pa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Z.","family":"Saunders","sequence":"additional","affiliation":[{"name":"Department of Pathology and Toxicology, Smith Kline & French Laboratories, Philadelphia, Pa."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1978,8,1]]},"reference":[{"key":"atypb1","unstructured":"Adami\u00a0J. G., Nicholls\u00a0A. G.The Principles of Pathology. Philadelphia: Lea & Febiger; 1911:807."},{"key":"atypb2","unstructured":"Bennington\u00a0J. L., Beckwith\u00a0J. B.Atlas of Tumor Pathology, 2nd series, fascicle 12: Tumors of the Kidney, Renal Pelvis and Ureter. Washington, D. C.: Armed Forces Institute of Pathology; 1975:103-104."},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1962.33"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(64)90065-1"},{"key":"atypb5","first-page":"2206","volume":"29","year":"1969","journal-title":"Cancer Res"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1976.tb23119.x"},{"key":"atypb7","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/j.1699-0463.1954.tb00301.x","volume":"34","year":"1954","journal-title":"Acta Pathol Microbiol Scand"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1038\/189858b0"},{"key":"atypb9","doi-asserted-by":"crossref","unstructured":"Guerin\u00a0M., Chouroulinkov\u00a0I., Riviere\u00a0M. R.The Kidney. Rouiller\u00a0C., Muller\u00a0A. F., ed. New York: Academic Press; 1969:199 230-255 238.","DOI":"10.1016\/B978-1-4832-2826-6.50009-8"},{"key":"atypb10","first-page":"1","volume":"22","year":"1975","journal-title":"Adv Cancer Res"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1964.30"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-87898-5_10"},{"key":"atypb13","first-page":"71","volume":"35","year":"1976","journal-title":"Lab Invest"},{"key":"atypb14","unstructured":"Kawai\u00a0K., Fukuda\u00a0K., Kimura\u00a0M.Effects and Dose-Response Relationships of Toxic Metals. Nordberg\u00a0G. F., ed. Amsterdam: Elsevier; 1976:345-350."},{"key":"atypb15","first-page":"234","volume":"16","year":"1958","journal-title":"Brit J Cancer"},{"key":"atypb16","first-page":"130","volume":"44","year":"1974","journal-title":"Recent Results in Cancer Res"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(71)90042-6"},{"key":"atypb18","unstructured":"Nordberg\u00a0G. F.Effects and Dose-Response Relationships of Toxic Metals. Amsterdam: Elsevier; 1976:60."},{"issue":"5","key":"atypb19","first-page":"5","volume":"15","year":"1978","journal-title":"Vet Path"},{"key":"atypb20","first-page":"297","volume":"41","year":"1962","journal-title":"Am J Path"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1965.99"},{"key":"atypb22","unstructured":"Schreiner\u00a0G. E.Structural Basis of Renal Disease. Becker\u00a0E. L., ed. New York: Harper & Row; 1968:730-740."},{"key":"atypb23","unstructured":"Snell\u00a0K.Pathology of Laboratory Rats and Mice. Cotchin\u00a0E., Roe\u00a0F. J. C., ed. Oxford: Blackwell Scientific Publications; 1967:105-147."},{"key":"atypb24","unstructured":"Sunderman\u00a0F. W.Nickel. Washington, D. C.: National Academy of Science; 165."},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1962.34"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/19.7.608"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(76)90185-X"},{"key":"atypb28","first-page":"9","volume":"20","year":"1969","journal-title":"Lab Invest"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(76)90099-5"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1007\/BF00956266"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985878015s0507","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300985878015s0507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:16:25Z","timestamp":1777662985000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300985878015s0507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,8]]},"references-count":30,"journal-issue":{"issue":"5_suppl","published-print":{"date-parts":[[1978,8]]}},"alternative-id":["10.1177\/0300985878015s0507"],"URL":"https:\/\/doi.org\/10.1177\/0300985878015s0507","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,8]]}}}