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The calcific deposits, found in both proximal and distal portions of cortical tubules, began either in the cytoplasm or in lysosomal bodies as a unilaminar spheroid structure containing apatite crystals. The ultrastructural characteristics of intraluminal concretions suggested that they were formed intracellularly but later were extruded into the lumen. The extent of calcific deposits increased with duration and with hypercalcemia. Although Cestrum contains an analog of 1,25-dihydroxycholecalciferol, neither mitochondria nor basal lamina contained calcific deposits described in nephrocalcinosis secondary to hypervitaminosis D.<\/jats:p>","DOI":"10.1177\/030098588101800107","type":"journal-article","created":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T16:42:42Z","timestamp":1484498562000},"page":"62-70","source":"Crossref","is-referenced-by-count":7,"title":["The Ultrastructure of Nephrocalcinosis Induced in Chicks by\n                    <i>Cestrum diurnum<\/i>\n                    Leaves"],"prefix":"10.1177","volume":"18","author":[{"given":"K.","family":"Sarkar","sequence":"first","affiliation":[{"name":"Departments of Pathology, Anatomy and Surgery, School of Medicine, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Narbaitz","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Anatomy and Surgery, School of Medicine, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Pokrupa","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Anatomy and Surgery, School of Medicine, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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