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The former were characterized by tubular structures lined by anaplastic cuboidal or columnar cells with diffuse fibrous stroma, and the latter by multiple cystic structures with papillary and solid areas. Half the bile duct cystadenocarcinomas showed benign cysts and transition to adenocarcinoma. This was seen in only one case of cholangiocarcinoma. The extrahepatic bile duct carcinoma was characterized by tubular structures lined with flattened cuboidal cells with scant stroma. The gall bladder adenocarcinoma contained many acinar structures lined with columnar or cuboidal cells and separated by thin stroma. Distant metastasis was found in 87.5% (21 of 24) of the bile duct adenocarcinomas; the lymph nodes, lungs and peritoneum were the common sites of metastasis.<\/jats:p>","DOI":"10.1177\/030098588101800403","type":"journal-article","created":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T07:04:15Z","timestamp":1484463855000},"page":"439-444","source":"Crossref","is-referenced-by-count":61,"title":["Canine Bile Duct Carcinoma"],"prefix":"10.1177","volume":"18","author":[{"given":"A. K.","family":"Patnaik","sequence":"first","affiliation":[{"name":"Department of Pathology and Department of Medicine, The Animal Medical Center, and Memorial Sloan-Kettering Cancer Center, New York, N.Y."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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