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Of the 30 dogs infected experimentally at 5 to 7 days of age with virulent R252 strain of canine distemper virus. 11 had gross or microscopic cardiac involvement as early as 16 days post-infection. The 25 dogs similarly infected at 10 to 21 days of age. the uninfected age-matched controls, and pups infected at 5 to 7 days of age with avirulent R252 canine distemper virus had no cardiac lesions. Although the lesions are attributed to a direct viral effect, they occur against a background of other canine distemper virus-related changes including immunosuppression, anemia and encephalomyelitis. All these factors may have a modifying role in the development of this age-dependent susceptibility to virus-associated myocardial necrosis.<\/jats:p>","DOI":"10.1177\/030098588101800406","type":"journal-article","created":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T07:04:15Z","timestamp":1484463855000},"page":"472-486","source":"Crossref","is-referenced-by-count":23,"title":["Canine Distemper Virus-Associated Cardiac Necrosis In The Dog"],"prefix":"10.1177","volume":"18","author":[{"given":"R. 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