{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:41:00Z","timestamp":1777920060823,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1981,7,1]],"date-time":"1981-07-01T00:00:00Z","timestamp":362793600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[1981,7]]},"abstract":"<jats:p>In a retrospective study of lymphomas in animals, tumors in 72 dogs, 81 cats and 90 cows were classified on the basis of cell size (small, medium and large), nuclear cleavage (follicular center cells), and histologic architecture (nodular or diffuse). Each subtype was classified by age of animal at death, number of metastases, breed, and sex. As in man, nodular cleaved tumors are rare in animals, the cow having the most varied tumor types. There was one cleaved-cell tumor in 72 lymphomas in dogs, 23 of 81 in cats, and 33 of 90 in cows. There were six nodular tumors of 72 in dogs, two of 81 in cats, and eight of 90 in cows. Fifteen of 16 nodular lymphomas had noncleaved cells and twelve had small or predominantly small cells. Cats with nodular lymphomas were older at death than cats with diffuse lymphomas. Nodularity was not associated with greater age at death in dogs and cows. Animals with cleaved-cell lymphomas were older at death than those with noncleaved tumors; this difference was highly significant in cows. The number of metastases was greater with nodular tumors in all three species, and was equal in cleaved and noncleaved tumors. The biological behaviour of lymphoid tumors in animals is similar to those in man when the same criteria of classification are used.<\/jats:p>","DOI":"10.1177\/030098588101800408","type":"journal-article","created":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T07:04:15Z","timestamp":1484463855000},"page":"494-512","source":"Crossref","is-referenced-by-count":36,"title":["Histocytology of Lymphoid Tumors in the Dog, Cat and Cow"],"prefix":"10.1177","volume":"18","author":[{"given":"V. E.","family":"Valli","sequence":"first","affiliation":[{"name":"Department of Pathology, Ontario Veterinary College, Guelph, Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. J.","family":"Mcsherry","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ontario Veterinary College, Guelph, Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. M.","family":"Dunham","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ontario Veterinary College, Guelph, Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. M.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ontario Veterinary College, Guelph, Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Lumsden","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ontario Veterinary College, Guelph, Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1981,7]]},"reference":[{"key":"e_1_2_2_2_1","unstructured":"Aleksandrowicz J. Janicki K.: The epidemiology of leukemia in Poland with a special regard to the Cracow region and its correlation with the cattle leukemia. Proc IXth Congr Eur Soc Hematol pp. 127\u2013129. Karger (Basel) Lisbon 1963"},{"key":"e_1_2_2_3_1","first-page":"343","article-title":"A classification of lymphoid neoplasms of domestic mammals.","volume":"32","author":"Anderson L. J.","year":"1968","unstructured":"Anderson L. J. Jarret W. F. H. Crighton G. W.: A classification of lymphoid neoplasms of domestic mammals. Natl Cancer Inst Monogr 32: 343\u2013353, 1968","journal-title":"Natl Cancer Inst Monogr"},{"key":"e_1_2_2_4_1","first-page":"p. 609","volume-title":"Veterinary Medicine","author":"Blood D. C.","year":"1979","unstructured":"Blood D. C. Henderson J. A. Radostits O. M.: Veterinary Medicine, 5th ed., p. 609\u2013614. Balliere and Tindall, London, 1979","edition":"5"},{"key":"e_1_2_2_5_1","first-page":"993","article-title":"Epizootiologic characteristics of canine and feline leukemia and lymphoma.","volume":"28","author":"Dorn C. R.","year":"1967","unstructured":"Dorn C. R. Taylor D. O. Hibbard H. H.: Epizootiologic characteristics of canine and feline leukemia and lymphoma. Am J Vet Res 28: 993\u20131001, 1967","journal-title":"Am J Vet Res"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000224686"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098586400100203"},{"key":"e_1_2_2_8_1","first-page":"152","volume-title":"The Reticuloendothelial System","author":"Hartsock R. J.","year":"1975","unstructured":"Hartsock R. J.: Reactive lesions in lymph nodes. In: The Reticuloendothelial System, ed. Rebuck, Berard, Abell. International Academy of Pathology Monograph no. 16, pp. 152\u2013183. Williams and Wilkins, Baltimore, 1975"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197304)31:4<806::AID-CNCR2820310408>3.0.CO;2-1"},{"key":"e_1_2_2_10_1","first-page":"386","volume-title":"Pathology of Domestic Animals I","author":"Jubb K. V.","year":"1970","unstructured":"Jubb K. V. Kennedy P. C.: Pathology of Domestic Animals I, 2nd ed., p. 386\u2013392. Academic Press, New York, 1970","edition":"2"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197403)33:3<657::AID-CNCR2820330311>3.0.CO;2-D"},{"key":"e_1_2_2_12_1","first-page":"195","volume-title":"Malignant Diseases of the Hematopoietic System","author":"Kojima M.","year":"1973","unstructured":"Kojima M. Imae Y. Mori N.: A concept of follicular lymphoma. A proposal for the existence of a neoplasm originating from the germinal center. In: Malignant Diseases of the Hematopoietic System, ed. Akazaki, Rappaport, Berard, Bennett, Ishikawa. Gann Monographs on Cancer Research, 1st ed., no. 15, pp. 195\u2013208. Univ. Tokyo Press, Japan, 1973"},{"key":"e_1_2_2_13_1","first-page":"217","volume-title":"Malignant Diseases of the Hematopoietic System","author":"Lennert K.","year":"1973","unstructured":"Lennert K.: Follicular lymphoma. A tumor of the germinal centers. In: Malignant Diseases of the Hematopoietic System, ed. Akazaki, Rappaport, Berard, Bennett, Ishikawa. Gann Monographs on Cancer Research, 1st ed., no. 15, pp. 217\u2013232. Univ. Tokyo Press, Japan, 1973"},{"key":"e_1_2_2_14_1","first-page":"213","volume-title":"The Reticuloendothelial System","author":"Lukes R. J.","year":"1975","unstructured":"Lukes R. J. Collins R. D.: A functional classification of malignant lymphomas. In: The Reticuloendothelial System, ed. Rebuck, Berard, Abell. International Academy of Pathology Monograph no. 16, pp. 213\u2013242. Williams and Wilkins, Baltimore, 1975"},{"key":"e_1_2_2_15_1","first-page":"260","article-title":"Organization and communication in populations of normal and leukemic hemopoietic cells.","volume":"355","author":"McCullock E. A.","year":"1974","unstructured":"McCullock E. A. Mak R. W. Price G. B. Till J. E.: Organization and communication in populations of normal and leukemic hemopoietic cells. Biochim Biophys Acta 355: 260\u2013299, 1974","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_2_16_1","first-page":"105","article-title":"Malignant lymphomas. A conceptual understanding of morphologic diversity.","volume":"94","author":"Mann R. B.","year":"1979","unstructured":"Mann R. B. Jaffe E. S. Berard C. W.: Malignant lymphomas. A conceptual understanding of morphologic diversity. Am J Pathol 94: 105\u2013192, 1979","journal-title":"Am J Pathol"},{"key":"e_1_2_2_17_1","volume-title":"Diagnostic Cell Pathology in Tissue and Smears","author":"Nieburgs H. E.","year":"1967","unstructured":"Nieburgs H. E.: Diagnostic Cell Pathology in Tissue and Smears. Grune and Stratton, New York, 1967"},{"key":"e_1_2_2_18_1","first-page":"73","article-title":"Spontaneous hematopoietic neoplasms of the domestic cat.","volume":"32","author":"Neilsen S. W.","year":"1969","unstructured":"Neilsen S. W.: Spontaneous hematopoietic neoplasms of the domestic cat. Natl Cancer Inst Mongr 32: 73\u201394, 1969","journal-title":"Natl Cancer Inst Mongr"},{"key":"e_1_2_2_19_1","first-page":"1651","volume-title":"Textbook of Veterinary Internal Medicine","author":"Prasse K. W.","year":"1975","unstructured":"Prasse K. W.: Disorders of the leukocytes. In: Textbook of Veterinary Internal Medicine, ed. Ettinger, vol. 2, pp. 1651\u20131653. W. B. Saunders, Philadelphia, 1975"},{"key":"e_1_2_2_20_1","first-page":"1","volume-title":"The Reticuloendothelial System","author":"Rappaport H.","year":"1975","unstructured":"Rappaport H. Braylan R. C.: Changing concepts in the classification of malignant neoplasms of the hematopoietic system. In: The Reticuloendothelial System, ed. Rebuck, Berard, Abell. International Academy of Pathology Monograph no. 16, pp. 1\u201319. Williams and Wilkins, Baltimore, 1975"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195607\/08)9:4<792::AID-CNCR2820090429>3.0.CO;2-B"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.168.3935.1098"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1973.162.03.217"},{"key":"e_1_2_2_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098586500200105"},{"key":"e_1_2_2_25_1","first-page":"208","volume-title":"Veterinary Pathology","author":"Smith H. A.","year":"1972","unstructured":"Smith H. A. Jones T. C. Hunt R. D.: Veterinary Pathology, 4th ed., p. 208\u2013214. Lea and Febiger, Philadelphia, 1972","edition":"4"},{"key":"e_1_2_2_26_1","first-page":"565","article-title":"Clinical and pathological study of canine lymphoma: clinical staging, cell classification and therapy.","volume":"51","author":"Squire R. A.","year":"1973","unstructured":"Squire R. A. Bush M. Melby E. C. Neeley L. M. Yarbrough B.: Clinical and pathological study of canine lymphoma: clinical staging, cell classification and therapy. J Natl Cancer Inst 51: 565\u2013574, 1973","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_2_27_1","first-page":"14","article-title":"Leukemia in animals and man.","volume":"108","author":"Theilen G. H.","year":"1968","unstructured":"Theilen G. H. Dungworth D. L. Kawakami T. G.: Leukemia in animals and man. Calif Med 108: 14\u201319, 1968","journal-title":"Calif Med"},{"key":"e_1_2_2_28_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(70)86266-X"},{"key":"e_1_2_2_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711120103"},{"key":"e_1_2_2_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(69)90242-3"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098588101800408","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098588101800408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:19:07Z","timestamp":1777663147000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030098588101800408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,7]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1981,7]]}},"alternative-id":["10.1177\/030098588101800408"],"URL":"https:\/\/doi.org\/10.1177\/030098588101800408","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,7]]}}}